PIP4K2C

PIP4K2C
Identifiers
Aliases	PIP4K2C, PIP5K2C, phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
External IDs	OMIM: 617104; MGI: 2152214; GeneCards: PIP4K2C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GK9
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,603,418 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,047,454 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; secondary oocyte; ; hair follicle; ; renal medulla; ; Region I of hippocampus proper; ; pons; ; nasal epithelium; ; buccal mucosa cell; ; nipple; ; islet of Langerhans;
	Top expressed in
	retinal pigment epithelium; ; neural layer of retina; ; primary motor cortex; ; pyloric antrum; ; human kidney; ; prefrontal cortex; ; epithelium of stomach; ; submandibular gland; ; parotid gland; ; CA3 field;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; phosphatidylinositol phosphate kinase activity; identical protein binding; ATP binding; 1-phosphatidylinositol-5-phosphate 4-kinase activity;
Cellular component	cytoplasm; cytosol; membrane; autophagosome; extracellular exosome;
Biological process	phosphatidylinositol metabolic process; positive regulation of autophagosome assembly; phosphorylation; phosphatidylinositol phosphate biosynthetic process; regulation of autophagy; phosphatidylinositol biosynthetic process; regulation of phosphatidylinositol 3-kinase signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	79837
	117150
	ENSG00000166908
	ENSMUSG00000025417
	Q8TBX8
	Q91XU3
	NM_001146258; NM_001146259; NM_001146260; NM_024779
	NM_054097; NM_001359280
	NP_001139730; NP_001139731; NP_001139732; NP_079055
	NP_473438; NP_001346209
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma is an enzyme in humans that is encoded by the PIP4K2C gene.^[5] It is one of the phosphatidylinositol 4-phosphate 5-kinases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166908 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025417 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma".

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C)

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166908 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025417 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma".

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[3]

[4]

[5]

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)