PAN3

PAN3
Identifiers
Aliases	PAN3, PAN3 poly(A) specific ribonuclease subunit, poly(A) specific ribonuclease subunit PAN3
External IDs	OMIM: 617448; MGI: 1919837; GeneCards: PAN3
Gene location (Human) Chr. Chromosome 13 (human) Band 13q12.2 Start 28,138,506 bp End 28,295,335 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G3 Start 147,366,971 bp End 147,485,312 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell secondary oocyte thymus trabecular bone epithelium of nasopharynx cerebellar vermis skin of arm mucosa of ileum germinal epithelium corpus epididymis Top expressed in zygote secondary oocyte genital tubercle tail of embryo spermatid thymus cerebellar cortex spermatocyte lobe of cerebellum neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function poly(A)-specific ribonuclease activity protein kinase activity nucleotide binding protein binding ATP binding metal ion binding RNA binding Cellular component cytoplasm cytosol PAN complex P-body Biological process protein phosphorylation protein targeting mRNA processing RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA poly(A) tail shortening deadenylation-dependent decapping of nuclear-transcribed mRNA positive regulation of cytoplasmic mRNA processing body assembly nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 255967 72587 Ensembl ENSG00000152520 ENSMUSG00000029647 UniProt Q58A45 Q640Q5 RefSeq (mRNA) NM_175854 NM_028291 NM_001359433 RefSeq (protein) NP_787050 NP_082567 NP_001346362 Location (UCSC) Chr 13: 28.14 – 28.3 Mb Chr 5: 147.37 – 147.49 Mb PubMed search
Wikidata
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PAN3 poly(A) specific ribonuclease subunit is a protein that in humans is encoded by the PAN3 gene. PAN3 is part of the PAN deadenylation complex involved in shortening mRNA.

See also

• PAN2

Further reading

• Uchida N, Hoshino S, Katada T (2004). "Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein". J. Biol. Chem. 279 (2): 1383–91. doi:10.1074/jbc.M309125200. PMID 14583602.