PAN2

PAN2
Identifiers
Aliases	PAN2, USP52, PAN2 poly(A) specific ribonuclease subunit, poly(A) specific ribonuclease subunit PAN2
External IDs	OMIM: 617447; MGI: 1918984; GeneCards: PAN2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,334,053 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,157,227 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; right uterine tube; ; left ovary; ; anterior pituitary; ; right ovary; ; body of pancreas; ; right testis; ; left testis;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; granulocyte; ; hair follicle; ; endocardial cushion; ; epithelium of lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; nuclease activity; exonuclease activity; 3'-5'-exoribonuclease activity; protein binding; hydrolase activity; nucleic acid binding; metal ion binding;
Cellular component	cytoplasm; PAN complex; cytosol; P-body; nucleus;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; mRNA processing; nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, exonucleolytic; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of cytoplasmic mRNA processing body assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9924
	103135
	ENSG00000135473
	ENSMUSG00000005682
	Q504Q3
	Q8BGF7
	NM_014871; NM_001127460; NM_001166279
	NM_001252326; NM_001252327; NM_133992; NM_001358822
	NP_001120932; NP_001159751; NP_055686
	NP_001239255; NP_001239256; NP_598753; NP_001345751
	Wikidata
View/Edit Human	View/Edit Mouse

PAB-dependent poly(A)-specific ribonuclease subunit 2 is an enzyme that in humans is encoded by the PAN2 gene (previously USP52).^[5]^[6]^[7] PAN2 is involved in the degradation of mRNA in the cytoplasm.^[8] In particular, PAN2 functions as an enzymatic core of the PAN deadenylation complex, one of the two major deadenylases in the cytoplasm involved in mRNA turnover.^[8] PAN specifically is stimulated by PABP, and shortens the poly(A) tails of RNA.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135473 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005682 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
↑ Uchida N, Hoshino S, Katada T (January 2004). "Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein". The Journal of Biological Chemistry. 279 (2): 1383–91. doi:10.1074/jbc.M309125200. PMID 14583602.
↑ "Entrez Gene: USP52 ubiquitin specific peptidase 52".
1 2 3 "Q504Q3 · PAN2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (April 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, Garabaya C, Cal S, López-Otín C (January 2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochemical and Biophysical Research Communications. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
Yamashita A, Chang TC, Yamashita Y, Zhu W, Zhong Z, Chen CY, Shyu AB (December 2005). "Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover". Nature Structural & Molecular Biology. 12 (12): 1054–63. doi:10.1038/nsmb1016. PMID 16284618. S2CID 19485927.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135473 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005682 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[pmid14583602-6] Uchida N, Hoshino S, Katada T (January 2004). "Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein". The Journal of Biological Chemistry. 279 (2): 1383–91. doi:10.1074/jbc.M309125200. PMID 14583602.

[entrez-7] "Entrez Gene: USP52 ubiquitin specific peptidase 52".

[uniprot-8] 1 2 3 "Q504Q3 · PAN2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-17.

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PAN2

See also

References

Further reading