Oliverpabstia intestinalis
| Oliverpabstia intestinalis | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Lachnospiraceae |
| Genus: | Oliverpabstia |
| Species: | O. intestinalis |
| Binomial name | |
| Oliverpabstia intestinalis Wylensek et al., 2021 | |
| Type strain | |
| BSM-380-WT-5A (= DSM 106162 = JCM 34394) | |
Oliverpabstia intestinalis is a species of Gram-positive, strictly anaerobic bacteria within the family Lachnospiraceae. It is the type species of the genus Oliverpabstia, first described in 2020 following its isolation from the gastrointestinal tract of pigs in Germany. The species name "intestinalis" reflects its origin from the intestinal environment.
Taxonomy
Oliverpabstia intestinalis was first described by Wylensek et al. in 2020, based on isolates obtained from the pig gastrointestinal tract. Phylogenetic analyses, including 16S rRNA gene sequencing and whole-genome comparisons, demonstrated that these isolates formed a distinct lineage within the Lachnospiraceae family, warranting the establishment of a new genus and species.[1]
Morphology and physiology
Members of the species O. intestinalis are characterized by the following features:
- Cell morphology: Gram-positive, non-spore-forming coccoid rods
- Oxygen requirement: Strictly anaerobic
- Temperature range: Mesophilic, with optimal growth at 37 °C
- Metabolism: Fermentative, producing short-chain fatty acids as metabolic end products
The type strain, BSM-380-WT-5A, was isolated from the feces of a 5-month-old pig in Germany.[2]
Ecology
Oliverpabstia intestinalis has been isolated from the gastrointestinal tracts of pigs and humans,[3] and macaques[4] suggesting a role in the gut microbiota of mammals. Specifically, strain DSM 113008 (JCM 35882) was isolated from the feces of a healthy adult male in Aachen, Germany, in 2020.[5]
In a study conducted in 2024 with 3,234 faecal samples from humans in rural China, a positive correlation was found between O. intestinalis and the frequency of defecation, but that O. intestinalis did not cause symptoms of diarrhoea or infection.[6]
Parkinson's disease
There has been research to suggest a reduced risk of Parkinson's disease due to coffee intake, but whether this is due to changes in gut microbiome or metabolism is not yet known.[7] A 2025 study investigated this and found that O. intestinalis was one of 56 microbes that were enriched with patients with Parkinson's disease and negatively correlated with caffeine and its metabolites.[7]
Pig farming
O. intestinalis was found to increase in abundance (alongside 140 other microbes) in the guts of pigs after weaning.[8][9] Metagemonic-assembled genomes (MAG's) are sequences from reconstructed genomes in a laboratory, and are used to help identify and record genomic data where the microbe itself may not be able to be directly cultured from the environment.[8] MAG's of O. intestinalis was also used as a predictor of resilience to post weaning diarrhoea in piglets.[10]
Prebiotics
Prebiotics are used to alter the gut biome for health benefits.[11] For conditions like Irritable Bowel Syndrome (IBS), there have been investigations into more convenient or effective methods of prebiotic delivery. In a 2025 study, a technology that allows host faecal microbiome (SIFR®) was used to create Bimuno® Galacto-oligosaccaride (GOS).[11] 8 humans were tested in the trial, where capsules of GOS were ingested and these prebiotics were able to modify the human gut biome, including the increase of O. intestinalis.[11]
See also
References
- ↑ Wylensek, D.; Hitch, T.C.A.; Riedel, T.; Afrizal, A.; Kumar, N.; Wortmann, E.; Liu, T.; Devendran, S.; Lesker, T.R.; Hernández, S.B. (2020). "A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity". Nature Communications. 11 (1) 6389. Bibcode:2020NatCo..11.6389W. doi:10.1038/s41467-020-19929-w. PMC 7738495. PMID 33303984.
- ↑ "Oliverpabstia intestinalis BSM-380-WT-5A". BacDive. Retrieved 2025-07-02.
- ↑ Laue, Hannah E.; Willis, Amy D.; Wang, Fang; MacDougall, Melinda C.; Xu, Yingying; Karagas, Margaret R.; Madan, Juliette C.; Fleisch, Abby F.; Lanphear, Bruce P.; Cecil, Kim M.; Yolton, Kimberly; Chen, Aimin; Buckley, Jessie P.; Braun, Joseph M. (2025-05-08). "Early-life and concurrent predictors of the healthy adolescent microbiome in a cohort study". Genome Medicine. 17 (1): 50. doi:10.1186/s13073-025-01481-1. ISSN 1756-994X. PMC 12060534. PMID 40340756.
- ↑ Purse, C.; Parker, A.; James, S. A.; Baker, D. J.; Moss, C. J.; Evans, R.; Durham, J.; Funnell, S. G. P.; Carding, S. R. (2025-05-14). "Intestinal microbiota profiles of captive-bred cynomolgus macaques reveal influence of biogeography and age". Animal Microbiome. 7 (1): 47. doi:10.1186/s42523-025-00409-9. ISSN 2524-4671. PMC 12080069. PMID 40369669.
- ↑ "Oliverpabstia intestinalis DSM 113008". Leibniz Institute DSMZ. Retrieved 2025-07-02.
- ↑ Huang, Pan; Dong, Quanbin; Wang, Yifeng; Tian, Yunfan; Wang, Shunhe; Zhang, Chengcheng; Yu, Leilei; Tian, Fengwei; Gao, Xiaoxiang; Guo, Hang; Yi, Shanrong; Li, Mingyang; Liu, Yang; Zhang, Qingsong; Lu, Wenwei (June 2024). "Gut microbial genomes with paired isolates from China illustrate probiotic and cardiometabolic effects". Cell Genomics. 4 (6) 100559. doi:10.1016/j.xgen.2024.100559. ISSN 2666-979X. PMC 11228888. PMID 38740021.
- 1 2 Chen, Chieh-Chang; Chiu, Jian-Ying; Tan, Ai Huey; Toh, Tzi Shin; Lim, Shen-Yang; Tan, Eng King; Pettersson, Sven; Hsu, Cheng-Chih; Liou, Jyh-Ming; Wu, Ming-Shiang; Hsu, Chia-Lang; Lin, Chin-Hsien (2025-05-27). "Investigating Plasma Metabolomics and Gut Microbiota Changes Associated With Parkinson Disease: A Focus on Caffeine Metabolism". Neurology. 104 (10) e213592. doi:10.1212/WNL.0000000000213592. ISSN 0028-3878. PMC 12022887. PMID 40273394.
- 1 2 Holman, Devin B.; Kommadath, Arun; Tingley, Jeffrey P.; Abbott, D. Wade (2022-07-26). "Novel Insights into the Pig Gut Microbiome Using Metagenome-Assembled Genomes". Microbiology Spectrum. 10 (4): e02380–22. doi:10.1128/spectrum.02380-22. PMC 9431278. PMID 35880887.
- ↑ Yi, Lanlan; Cheng, Wenjie; Song, Guangyao; Jia, Huijin; Xie, Yuxiao; Zhang, Wanghong; Zhu, Junhong; Zhao, Sumei (2025-08-31). "Integrating Machine Learning to Identify Key Microbiota of Gut Community Changes Across Different Stages in Dahe Black Pigs". Microorganisms. 13 (9): 2038. doi:10.3390/microorganisms13092038. ISSN 2076-2607. PMC 12471813. PMID 41011369.
- ↑ Pirolo, Mattia; Sherwani, Moiz Khan; Espinosa-Gongora, Carmen; Eriksen, Esben Østergaard; Tassinato, Clara; Alberdi, Antton; Guardabassi, Luca (2026-02-24). "Faecal microbiome profiling uncovers putative biomarkers for piglets resilient to post-weaning diarrhoea". Animal Microbiome. 8 (1): 33. doi:10.1186/s42523-026-00522-3. ISSN 2524-4671. PMC 13040825. PMID 41736110.
- 1 2 3 Harthoorn, Lucien F.; Heyse, Jasmine; Baudot, Aurélien; van Hengel, Ingmar A. J.; Van den Abbeele, Pieter (2025-08-05). "Galacto-Oligosaccharides Exert Bifidogenic Effects at Capsule-Compatible Ultra-Low Doses". Metabolites. 15 (8): 530. doi:10.3390/metabo15080530. ISSN 2218-1989. PMC 12388037. PMID 40863149.