Nucleoside deoxyribosyltransferase
| nucleoside deoxyribosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Nucleoside 2-deoxyribosyltransferase homohexamer, Lactobacillus leichmannii | |||||||||
| Identifiers | |||||||||
| EC no. | 2.4.2.6 | ||||||||
| CAS no. | 9026-86-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a nucleoside deoxyribosyltransferase (EC 2.4.2.6) is an enzyme that catalyzes the chemical reaction
- 2-deoxy-D-ribosyl-base1 + base2 2-deoxy-D-ribosyl-base2 + base1
Thus, the two substrates of this enzyme are 2-deoxy-D-ribosyl-base1 and base2, whereas its two products are 2-deoxy-D-ribosyl-base2 and base1.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase. Other names in common use include purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl, transferase, deoxyribose transferase, nucleoside trans-N-deoxyribosylase, trans-deoxyribosylase, trans-N-deoxyribosylase, trans-N-glycosidase, nucleoside deoxyribosyltransferase I (purine nucleoside:purine, deoxyribosyltransferase: strictly specific for transfer between, purine bases), nucleoside deoxyribosyltransferase II [purine(pyrimidine), and nucleoside:purine(pyrimidine) deoxyribosyltransferase]. This enzyme participates in pyrimidine metabolism.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1F8X, PDB: 1F8Y, PDB: 1S2D, PDB: 1S2G, PDB: 1S2I, PDB: 1S2L, PDB: 1S3F, PDB: 2A0K, PDB: 2F2T, PDB: 2F62, PDB: 2F64, and PDB: 2F67.
References
- KALCKAR HM, MACNUTT WS, HOFF-JORGENSEN E (1952). "Trans-N-glycosidase studied with radioactive adenine". Biochem. J. 50 (3): 397–400. doi:10.1042/bj0500397. PMC 1197666. PMID 14915963.
- MACNUTT WS (1952). "The enzymically catalysed transfer of the deoxyribosyl group from one purine or pyrimidine to another". Biochem. J. 50 (3): 384–97. doi:10.1042/bj0500384. PMC 1197665. PMID 14915962.
- ROUSH AH, BETZ RF (1958). "Purification and properties of trans-N-deoxyribosylase". J. Biol. Chem. 233 (2): 261–6. doi:10.1016/S0021-9258(18)64745-3. PMID 13563482.