NLRP10

NLRP10
Identifiers
Aliases	NLRP10, CLR11.1, NALP10, NOD8, PAN5, PYNOD, NLR family, pyrin domain containing 10, NLR family pyrin domain containing 10
External IDs	OMIM: 609662; MGI: 2444084; GeneCards: NLRP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M5V
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 7,957,537 bp End 7,965,447 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E3 Start 108,521,059 bp End 108,529,385 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg testicle skin of abdomen stromal cell of endometrium placenta Achilles tendon appendix gastrocnemius muscle lactiferous gland smooth muscle tissue Top expressed in interventricular septum esophagus lip skin of external ear myocardium of ventricle skin of back umbilical cord atrioventricular valve skin of abdomen atrium More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ATP binding GTPase activity ATPase activity Cellular component plasma membrane extrinsic component of plasma membrane membrane cytoplasm Biological process innate immune response adaptive immune response defense response to Gram-negative bacterium immune system process positive regulation of T-helper 17 type immune response defense response to fungus positive regulation of T-helper 1 type immune response positive regulation of inflammatory response positive regulation of defense response to bacterium inflammatory response Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 338322 244202 Ensembl ENSG00000276780 ENSG00000281166 ENSG00000182261 ENSMUSG00000049709 UniProt Q86W26 Q8CCN1 RefSeq (mRNA) NM_176821 NM_001391958 NM_175532 RefSeq (protein) NP_789791 NP_780741 Location (UCSC) Chr 11: 7.96 – 7.97 Mb Chr 7: 108.52 – 108.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP10 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.

Further reading

• Wang Y, Hasegawa M, Imamura R, et al. (2004). "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1". Int. Immunol. 16 (6): 777–86. doi:10.1093/intimm/dxh081. hdl:2297/15871. PMID 15096476.
• Kinoshita T, Wang Y, Hasegawa M, et al. (2005). "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion". J. Biol. Chem. 280 (23): 21720–5. doi:10.1074/jbc.M410057200. hdl:2297/2649. PMID 15817483.
• Zheng D, Mohapatra G, Kern L, et al. (2023). "Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation". Nat. Immunology. 24 (4): 585–594. doi:10.1038/s41590-023-01450-z. PMID 36941399. S2CID 257639248.
• Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ha HJ, Kim DS, Hahn Y (2009). "A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence". Biochem. Genet. 47 (9–10): 665–70. doi:10.1007/s10528-009-9262-2. PMID 19544093. S2CID 31002187.
• Ha HJ, Kim DS, Hahn Y (2009). "A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence". Biochem. Genet. 47 (9–10): 665–70. doi:10.1007/s10528-009-9262-2. PMID 19544093. S2CID 31002187.