NADH kinase
| NADH kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.86 | ||||||||
| CAS no. | 62213-39-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
NADH kinase (EC 2.7.1.86) is an enzyme that catalyzes the chemical reaction.
The enzyme characterised from yeast converts nicotinamide adenine dinucleotide to nicotinamide adenine dinucleotide phosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1] The enzyme is encoded by the gene NADK2.[2]
This enzyme is a transferases, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:NADH 2'-phosphotransferase. Other names in common use include reduced nicotinamide adenine dinucleotide kinase (phosphorylating), DPNH kinase, reduced diphosphopyridine nucleotide kinase, and NADH kinase. This enzyme has at least one activator, acetate.[3]
References
- ↑ Griffiths MM, Bernofsky C (1972). "Purification and properties of reduced diphosphopyridine nucleotide kinase from yeast mitochondria". J. Biol. Chem. 247 (5): 1473–8. doi:10.1016/S0021-9258(19)45582-8. PMID 4335000.
- ↑ Zhang, Ren; Zhang, Kezhong (2023-04-01). "Mitochondrial NAD kinase in health and disease". Redox Biology. 60 102613. doi:10.1016/j.redox.2023.102613. ISSN 2213-2317. PMC 9873681. PMID 36689815.
- ↑ Enzyme 2.7.1.86 at KEGG Pathway Database.