MB21D1

CGAS
Identifiers
Aliases	CGAS, C6orf150, cGAS, h-cGAS, Mab-21 domain containing 1, MB21D1, cyclic GMP-AMP synthase, Cyclic GMP-AMP synthase
External IDs	OMIM: 613973; MGI: 2442261; GeneCards: CGAS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4LEW, 4KM5, 4O67, 4MKP, 4LEV, 4O68, 4O69
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	73,452,297 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	78,350,519 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; buccal mucosa cell; ; endothelial cell; ; monocyte; ; bone marrow cell; ; granulocyte; ; blood; ; lymph node; ; external globus pallidus; ; cardia;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; zygote; ; spermatocyte; ; Paneth cell; ; vas deferens; ; condyle; ; fossa; ; conjunctival fornix; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotidyltransferase activity; nucleotide binding; metal ion binding; GTP binding; transferase activity; ATP binding; DNA binding; 2',3'-cyclic GMP-AMP synthase activity; double-stranded DNA binding; chromatin binding; protein binding;
Cellular component	cytoplasm; cytosol;
Biological process	immune system process; cyclic nucleotide biosynthetic process; cellular response to exogenous dsRNA; innate immune response; activation of innate immune response; defense response to virus; positive regulation of defense response to virus by host; cellular response to DNA damage stimulus; positive regulation of type I interferon production; paracrine signaling; positive regulation of cellular senescence; positive regulation of cGMP-mediated signaling; positive regulation of cAMP-mediated signaling; regulation of immunoglobulin production; determination of adult lifespan; regulation of type I interferon production; regulation of immune response; regulation of T cell activation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	115004
	214763
	ENSG00000164430
	ENSMUSG00000032344
	Q8N884
	Q8C6L5
	NM_138441
	NM_173386
	NP_612450
	NP_775562
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic GMP-AMP synthase is an enzyme that in humans is encoded by the CGAS gene (previously MB21D1).^[5] In particular, it functions as a cyclic GMP-AMP synthase,^[5] which is a type of nucleotidyltransferase.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164430 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032344 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]". Retrieved 2020-09-12.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Cyclic GMP-AMP synthase (MB21D1)

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164430 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032344 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]". Retrieved 2020-09-12.

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References

Further reading

External links