| Article | Location | Date | Number killed | Number injured | Description |
| Jim Jumper massacre | St. Lucie County | February 14 or 15, 1889 | 7+ | 1 | Killing of Seminoles |
| Rosewood massacre | Levy County | January 1923 | 8+ | Unknown | Racially motivated massacre of black people and the destruction of a black town |
| Carol City murders | Carol City | July 27, 1977 | 6 | 2 | Mass shooting at a drug house |
| Murder of Frances Slater | Stuart | April 27, 1982 | 1 | 0 | Kidnapping and murder of a business magnate's granddaughter |
| 1986 FBI Miami shootout | Dade County | April 11, 1986 | 4 | 5 | Shootout between robbers and FBI agents |
| Murder of Richard Raczkoski | Vero Beach, Florida | September 23, 1986 | 1 | 0 | The first Indian River County police officer to be murdered in the line of duty. |
| 1987 Palm Bay shooting | Palm Bay | April 23, 1987 | 6 | 14 | Mass shooting |
| James Edward Pough | Jacksonville | June 17–18, 1990 | 11 | 6 | Shooting spree |
| Murder of Danny Parrish | Fort Pierce, Florida | January 18, 1991 | 1 | 0 | Shooting and murder of a Fort Pierce police officer |
| Murders of Greg and Kimberly Malnory | Charlotte County | April 6, 1997 | 2 | 1 | Robbery and murder of a couple in a fish farm |
| murder of Kazue Perron | West Palm Beach, Florida | November 14, 1997 | 1 | 0 | Carjacking and murder of a Japanese woman |
| 1998 Crestview family murders | Crestview, Florida | September 11, 1998 | 4 | 0 | Mass shooting |
| 2003 Mayport murders | Mayport | May 14–23, 2003 | 5 | 0 | Mass murder |
| Killing of Rigoberto Alpizar | Miami-Dade County | December 7, 2005 | 1 | 0 | Fatal shooting of unarmed man by Federal Air Marshals |
| 2006 Ocala National Forest murders | Ocala National Forest | January 4, 2006 | 2 | 0 | Robbery and double murder of campers at the Ocala National Forest |
| 2009 Thanksgiving murders | Jupiter, Florida | November 26, 2009 | 4 | 1 | Mass shooting |
| murder of Seath Jackson | Summerfield, Florida | April 17, 2011 | 1 | 0 | Murder and dismemberment of a 15-year-old boy |
| Killing of Trayvon Martin | Sanford | February 26, 2012 | 1 | 0 | Fatal shooting of unarmed African-American boy |
| Murder of Jordan Davis | Jacksonville | November 23, 2012 | 1 | 0 | Fatal shooting of unarmed African-American boy |
| 2013 Hialeah shooting | Hialeah | July 26–27, 2013 | 7 | 0 | Mass shooting |
| 2014 shooting | Florida State University | November 19–20, 2014 | 0 | 3 | School shooting |
| Murder of Christina Grimmie | Orlando | June 10, 2016 | 2 | 0 | Murder-suicide |
| Pulse nightclub shooting | Orlando | June 12, 2016 | 49 | 58 | Terrorist attack/mass shooting; deadliest U.S. mass shooting at the time |
| Fort Lauderdale airport shooting | Broward County | January 6, 2017 | 5 | 42 | Mass shooting |
| Orlando factory shooting | Orlando | June 5, 2017 | 6 | 0 | Workplace shooting |
| Parkland high school shooting | Parkland | February 14, 2018 | 17 | 17 | School shooting |
| Murder of XXXTentacion | Deerfield Beach, Florida | June 18, 2018 | 1 | 0 | Robbery and murder of a singer-songwriter and rapper |
| Jacksonville Landing shooting | Jacksonville | August 26, 2018 | 3 | 11 | Mass shooting |
| 2018 Tallahassee shooting | Tallahassee | November 2, 2018 | 3 | 5 | Mass shooting |
| 2019 Sebring shooting | Sebring | January 23, 2019 | 5 | 0 | Mass shooting |
| 2019 Miramar shootout | Miramar | December 5, 2019 | 4 | 1 | Shootout between robbers/carjackers and police |
| Naval Air Station Pensacola shooting | Pensacola | December 6, 2019 | 4 | 8 | Terrorist attack/mass shooting |
| 2021 Sunrise, Florida shootout | Sunrise | February 2, 2021 | 3 | 3 | Shootout between suspected pedophile and FBI agents |
| 2021 Hialeah shooting | Hialeah | May 30, 2021 | 3 | 20 | Gang-related violence |
| Murder of Joshua Moyers | Nassau County, Florida | September 23, 2021 | 1 | 0 | Murder of a Nassau County Sheriff's Deputy in 2021 |
| 2023 Jacksonville shooting | Jacksonville, Florida | August 26, 2023 | 4 | 0 | Racially motivated hate crime |
| Murder of Julio Foolio | Tampa, Florida | June 23, 2024 | 1 | 3 | Mass shooting and gang-motivated murder of a rapper |
| 2024 Orlando Halloween shooting | Orlando | November 1, 2024 | 2 | 8 | Mass shooting |
| 2025 Florida State University shooting | Tallahassee | April 17, 2025 | 2 | 7 | School shooting |
| 2026 Fort Lauderdale–Sarasota shootings | Fort Lauderdale and Bee Ridge | February 10, 2026 | 7 | 0 | Spree shooting |