| Country | Name | Birthplace | Most recent MLS team | Former MLS team(s) | Notes | Refs |
Argentina  | Luciano Abecasis | Rosario, Argentina | San Jose (2021) | | | |
| Ramón Ábila | Córdoba, Argentina | D.C. United (2022) | Minnesota (2021) | | |
| Luciano Acosta | Buenos Aires, Argentina | D.C. United, Cincinnati, Dallas (2016–19, 2021–25) | | | |
| Ignacio Aliseda | Buenos Aires, Argentina | Chicago (2020–21) | | | |
| Tadeo Allende | Mina Clavero, Argentina | Inter Miami (2025–present) | | | |
| Thiago Almada | Ciudadela, Argentina | Atlanta (2022–24) | | | |
| Favio Álvarez | Córdoba, Argentina | LA Galaxy (2019) | | | |
| Adrián Arregui | Berazategui, Argentina | Montreal (2017) | | | |
| Yamil Asad | San Antonio de Padua, Argentina | Cincinnati (2024) | Atlanta (2017), D.C. United (2018, 2020–21, 2023) | | |
| Julián Aude | Lanús, Argentina | LA Galaxy (2023–present) | | | |
| Tomás Avilés | Río Gallegos, Argentina | Montréal (2026) | Inter Miami (2023–26) | Capped for Chile's national U20 football team | |
| David Ayala | Berazategui, Argentina | Inter Miami (2026–present) | Portland (2022–25) | | |
| Elías Báez | | Atlanta (2026–present) | | | |
| Mateo Bajamich | Morrison, Argentina | Houston (2021) | | | |
| Esequiel Barco | Villa Gobernador Gálvez, Argentina | Atlanta (2018–21) | | | |
| Álvaro Barreal | Buenos Aires, Argentina | Cincinnati (2020–23) | | | |
| Leandro Barrera | Godoy Cruz, Argentina | San Jose (2015) | Chivas USA (2014) | | |
| Guillermo Barros Schelotto | La Plata, Argentina | Columbus (2007–10) | | | |
| Nehuén Benedetti | Bosques, Argentina | New York Red Bulls (2026–present) | | | |
| Claudio Benetti | Córdoba, Argentina | Dallas (1999–2000) | | | |
| Hernán Bernardello | Rosario, Argentina | Montreal (2013–14, 2016–17) | | | |
| Claudio Bieler | Vera, Argentina | Kansas City (2013–14) | | | |
| Sebastián Blanco | Lomas de Zamora, Argentina | Portland (2017–23) | | | |
| Emiliano Bonfigli | Bahía Blanca, Argentina | Salt Lake (2012) | | | |
| Martín Bonjour | Carhué, Argentina | Vancouver (2012) | | | |
| Gustavo Bou | Concordia, Argentina | New England (2019–23) | | | |
| Agustín Bouzat | Bahía Blanca, Argentina | Houston (2026–present) | | | |
| Claudio Bravo | Lomas de Zamora, Argentina | Portland (2021–25) | | | |
| Federico Bravo | Jesús María, Argentina | New York City FC (2016) | | | |
| Víctor Cabrera | Lules, Argentina | Houston (2020) | Montreal (2015–19) | | |
| Franco Caraccio | Chacabuco, Argentina | Houston (2008) | | | |
| Milton Caraglio | Rosario, Argentina | New England (2011) | | | |
| Julián Carranza | Oncativo, Argentina | Philadelphia (2022–24) | Inter Miami (2020) | | |
| Marcelo Carrera | Buenos Aires, Argentina | Columbus (1996–98) | | | |
| Valentín Castellanos | Mendoza, Argentina | New York City FC (2018–22) | | | |
| Emanuel Cecchini | Ingeniero Huergo, Argentina | Seattle (2019) | | | |
| Tomás Chancalay | Viale, Argentina | Minnesota (2026–present) | New England (2023–25) | | |
| Ezequiel Cirigliano | Caseros, Argentina | Dallas (2015) | | | |
| Eloy Colombano | Pehuajo, Argentina | Kansas City (2007–08) | | | |
| Tomás Conechny | Comodoro Rivadavia, Argentina | Portland (2018–20) | | | |
| Enzo Copetti | Roque Sáenz Peña, Argentina | Charlotte (2023–24) | | | |
| Matías Córdoba | Lanús, Argentina | Salt Lake (2008) | | | |
| Facundo Coria | Buenos Aires, Argentina | D.C. United (2015) | | | |
| Franco Coria | Los Toldos, Argentina | New England (2011) | | | |
| Eduardo Coudet | Buenos Aires, Argentina | Philadelphia (2010) | | | |
| Emil Cuello | Buenos Aires, Argentina | LA Galaxy (2019–20) | | | |
| Braian Cufré | Mar del Plata, Argentina | New York City FC (2023) | | | |
| Cristian da Silva | Rosario, Argentina | MetroStars (1996–98) | | | |
| Pedro de la Vega | Olavarría, Argentina | Seattle (2024–present) | | | |
| Rodrigo De Paul | Sarandí, Argentina | Inter Miami (2025–present) | | | |
| Mauro Díaz | Concepción del Uruguay, Argentina | Dallas (2013–18) | | | |
| Facundo Diz | Argentina | Colorado (2009) | | | |
| Eduardo Domínguez | Lanús, Argentina | LA Galaxy (2008) | | | |
| Matías Donnet | Esperanza, Argentina | D.C. United (2006) | | | |
| Sebastián Driussi | San Justo, Argentina | Austin (2021–24) | | | |
| Nicolás Dubersarsky | Córdoba, Argentina | Austin (2025–26) | | | |
| Emiliano Dudar | Buenos Aires, Argentina | D.C. United (2012) | | | |
| Ramiro Enrique | Burzaco, Argentina | Orlando (2023–present) | | | |
| Facundo Erpen | Gualeguaychú, Argentina | Colorado (2007–08) | D.C. United (2005–07) | | |
| Luis Miguel Escalada | Ceres, Argentina | Salt Lake (2009) | | | |
| Franco Escobar | Rosario, Argentina | Houston (2023–25) | Atlanta (2018–20), Los Angeles FC (2022) | | |
| Fabián Espíndola | Merlo, Argentina | D.C. United (2013–16) | Salt Lake (2009–12), New York Red Bulls (2013) | | |
| Cristian Espinoza | Buenos Aires, Argentina | Nashville (2026–present) | San Jose (2019–25) | | |
| Darío Fabbro | General Deheza, Argentina | New England (2003) | Kansas City (2002–03) | | |
| Alejandro Farías | Buenos Aires, Argentina | New England (1997) | | | |
| Facundo Farías | Santa Fe, Argentina | Inter Miami (2023) | | | |
| Brian Fernández | Santa Fe, Argentina | Portland (2019) | | | |
| Gastón Fernández | Lanús, Argentina | Portland (2014–15) | | | |
| Julián Fernández | Buenos Aires, Argentina | New York City FC (2023–25) | | | |
| Nicolás Fernández | Buenos Aires, Argentina | New York City FC (2025–present) | | | |
| Nicolás Figal | América, Argentina | Inter Miami (2020–21) | | | |
| Lucio Filomeno | Capital Federal, Argentina | D.C. United (2005–06) | | | |
| Juan Forchetti | Tres Arroyos, Argentina | MetroStars (2003) | | | |
| Franco Fragapane | Las Heras, Argentina | Minnesota (2021–24) | | | |
| Alan Franco | Avellaneda, Argentina | Atlanta (2021–22) | | | |
| Nicolás Freire | Santa Lucía, Argentina | Inter Miami (2024) | | | |
| Nicolás Gaitán | San Martín, Argentina | Chicago (2019) | | | |
| Marcelo Gallardo | Merlo, Argentina | D.C. United (2008) | | | |
| Braian Galván | San Miguel de Tucumán, Argentina | Colorado (2020–21, 2023) | | | |
| José Galván | San Miguel de Tucumán, Argentina | MetroStars (2003) | | | |
| Sergio Galván Rey | Concepción, Argentina | MetroStars (2004–05) | | | |
| Walter García | Buenos Aires, Argentina | New York Red Bulls (2009) | | | |
| Lautaro Giaccone | San Francisco, Argentina | Columbus (2026–present) | | | |
| Ian Glavinovich | | Philadelphia (2025) | | | |
| Érik Godoy | Buenos Aires, Argentina | Vancouver (2019–22) | | | |
| Christian Gómez | Buenos Aires | Colorado (2008) | D.C. United (2004–07) | | |
| Ignacio Gómez | | Orlando (2026–present) | | | |
| Gastón González | Santa Fe, Argentina | Orlando (2023) | | | |
| Nelson González | Berazategui, Argentina | Salt Lake (2010–11) | | | |
| Leandro González Pírez | Buenos Aires, Argentina | Inter Miami (2020–21) | Atlanta (2017–19) | | |
| Mario Gori | Rosario, Argentina | Columbus (2000) | D.C. United (1996–98), Miami Fusion (1999), New England (1999) | | |
| Hernán Grana | Quilmes, Argentina | Dallas (2017) | Columbus (2015) | | |
| Sebastián Grazzini | Rosario, Argentina | Chicago (2011–12) | | | |
| Guillermo Hauche | La Plata, Argentina | New England (2018) | | | |
| Nicolás Hernández | Buenos Aires, Argentina | Columbus (2008) | Colorado (2006–08) | | |
| Marcelo Herrera | San Salvador de Jujuy, Argentina | Miami Fusion (1998) | | | |
| Marcelo Herrera | Corrientes, Argentina | Columbus (2024–present) | | | |
| Federico Higuaín | Buenos Aires, Argentina | Inter Miami (2020–21) | Columbus (2012–19), D.C. United (2010) | | |
| Gonzalo Higuaín | Brest, France | Inter Miami (2020–22) | | | |
| Santiago Hirsig | San Isidro, Argentina | Kansas City (2009–10) | | | |
| Lucas Hoyos | Guaymallén, Argentina | Atlanta (2026–present) | | | |
| Franco Ibarra | Tigre, Argentina | Toronto (2023) | Atlanta (2021–23) | | |
| Andrés Imperiale | Rosario, Argentina | San Jose (2016–17) | | | |
| Emiliano Insúa | Buenos Aires, Argentina | LA Galaxy (2020) | | | |
| Ricardo Iribarren | Berisso, Argentina | Columbus, Dallas (1996, 1998, 2000) | | | |
| Tomás Jacob | Santa Fe, Argentina | Atlanta (2026–present) | | | |
| Sebastián Jaime | La Plata, Argentina | Salt Lake (2014–15) | | | |
| Lucas Janson | Olavarría, Argentina | Toronto (2018) | | | |
| Agustin Jara | Corral de Bustos, Argentina | Dallas (2016) | | | |
| Franco Jara | Villa María, Argentina | Dallas (2020–22) | | | |
| Leonardo Jara | Corrientes, Argentina | D.C. United (2019) | | | |
| Matías Laba | Villa Raffo, Argentina | Vancouver (2014–17) | Toronto (2013) | | |
| Luca Langoni | Gregorio de Laferrère, Argentina | New England (2024–present) | | | |
| Carlos Ledesma | Argentina | MetroStars (1998) | | | |
| Emmanuel Ledesma | Quilmes, Argentina | Cincinnati (2019) | | | |
| Claudio López | Río Tercero, Argentina | Colorado (2010) | Kansas City (2008–09) | | |
| Hernán López | Villa del Parque, Argentina | San Jose (2024–25) | | | |
| Lisandro López | Rafael Obligado, Argentina | Atlanta (2021) | | | |
| Miguel López | Ensenada | LA Galaxy (2011) | | | |
| Gonzalo Luján | Buenos Aires, Argentina | Inter Miami (2025–present) | | | |
| Emanuel Maciel | José C. Paz, Argentina | Montreal (2020–21) | | | |
| Cristian Maidana | Resistencia, Argentina | Houston (2016) | Philadelphia (2014–15) | | |
| Matias Mantilla | Buenos Aires, Argentina | Salt Lake (2007–08) | | | |
| Carlos Marinelli | Villa de Mayo, Argentina | Kansas City (2007–08) | | | |
| Diego Martínez | General Pacheco, Argentina | New York City FC (2016) | | | |
| Pity Martínez | Guayamallén, Argentina | Atlanta (2019–20) | | | |
| Juan Manuel Martínez | Viedma, Argentina | Salt Lake (2015–16) | | | |
| Tomás Martínez | Béccar, Argentina | Houston (2017–20) | | | |
| Emmanuel Mas | San Juan, Argentina | Orlando (2021) | | | |
| Lucas Melano | Hernando, Argentina | Portland (2015–16) | | | |
| Jonathan Menéndez | Buenos Aires, Argentina | Salt Lake (2021–22) | | | |
| Lionel Messi | Rosario, Argentina | Inter Miami (2023–present) | | | |
| Fernando Meza | San Martín, Argentina | Atlanta (2020) | | | |
| Sergio Miguez | San Isidro, Argentina | Columbus (1997) | | | |
| Mariano Miño | Tigre, Argentina | Toronto (2018) | | | |
| Leonel Miranda | Avellaneda, Argentina | Houston (2015–16) | | | |
| Marcos Mondaini | Sáenz Peña, Argentina | Chivas USA (2011) | | | |
| Javier Morales | Buenos Aires, Argentina | Dallas (2017) | Salt Lake (2007–16) | | |
| Maximiliano Moralez | Granadero Baigorria, Argentina | New York City FC (2017–present) | | | |
| Marcelino Moreno | San Martín, Argentina | Atlanta (2020–22) | | | |
| Facundo Mura | General Roca, Argentina | Inter Miami (2026–present) | | | |
| Federico Navarro | Frontera, Argentina | Chicago (2021–24) | | | |
| Beto Naveda | San Juan, Argentina | New England (1996–97) | | | |
| Franco Negri | San Martín, Argentina | Houston (2026–present) | Inter Miami (2023–24), San Diego (2025) | | |
| Franco Niell | Trelew, Argentina | D.C. United (2008) | | | |
| Agustín Ojeda | Rosario, Argentina | New York City FC (2024–present) | | | |
| Martín Ojeda | Gualeguaychú, Argentina | Orlando (2023–present) | | | |
| Lucas Ontivero | Catamarca, Argentina | Montreal (2016) | | | |
| Luca Orellano | Francisco Álvarez, Argentina | Cincinnati (2024–25) | | | |
| Christian Ortiz | Rosario, Argentina | Charlotte (2022) | | | |
| Rodrigo Pacheco | Buenos Aires, Argentina | Los Angeles FC (2018) | | | |
| Gino Padula | Lanús, Argentina | Columbus (2008–10) | | | |
| Norberto Paparatto | Adrogué, Argentina | Portland (2014–15) | | | |
| Cristian Pavón | Córdoba, Argentina | LA Galaxy (2019–20) | | | |
| Daniel Peinado | San Rafael, Argentina | Dallas (1997) | | | |
| Matías Pellegrini | Magdalena, Argentina | New York City FC (2023) | Inter Miami (2020, 2022) | | |
| Agustín Pelletieri | Buenos Aires, Argentina | Chivas USA (2014) | | | |
| Gonzalo Peralta | Munro, Argentina | D.C. United (2008) | | | |
| Joaquín Pereyra | Paraná, Argentina | Minnesota (2024–present) | | | |
| Matías Pérez García | Tartagal, Argentina | Orlando (2016–17) | San Jose (2014–16) | | |
| Ignacio Piatti | General Baldissera, Argentina | Montreal (2014–19) | | | |
| Pablo Piatti | Ucacha, Argentina | Toronto (2020) | | | |
| Juan Pietravallo | Buenos Aires, Argentina | New York Red Bulls (2008–09) | | | |
| Lucas Pittinari | Laborde, Argentina | Colorado (2015) | | | |
| Tomás Pochettino | Rafaela, Argentina | Austin (2021) | | | |
| Ezequiel Ponce | Rosario, Argentina | Houston (2024–26) | | | |
| Facundo Quignon | Buenos Aires, Argentina | Dallas (2021–23) | | | |
| Juan Ramírez | Moreno, Argentina | Colorado (2015) | | | |
| Federico Redondo | Madrid, Spain | Inter Miami (2024–25) | | | |
| Eric Remedi | Paraná, Argentina | San Jose (2021–22) | Atlanta (2018–21) | | |
| Agustin Resch | | Houston (2026–present) | | | |
| Emanuel Reynoso | Córdoba, Argentina | Minnesota (2020–24) | | | |
| Pablo Ricchetti | Buenos Aires, Argentina | Dallas (2007–09) | | | |
| Emiliano Rigoni | Colonia Caroya, Argentina | Austin (2022–24) | | | |
| Andrés Ríos | Buenos Aires, Argentina | San Jose (2019–21) | | | |
| Rocco Ríos Novo | Los Angeles, US | Inter Miami (2025–present) | Atlanta (2022) | | |
| Martín Rivero | Roldán, Argentina | Chivas USA (2014) | Colorado (2012–13) | | |
| Javier Robles | Buenos Aires, Argentina | San Jose (2010) | | | |
| Baltasar Rodríguez | Monte Hermoso, Argentina | Inter Miami (2025) | | | |
| Lucas Rodríguez | Buenos Aires, Argentina | D.C. United (2019) | | | |
| Andrés Romero | Bell Ville, Argentina | Montreal (2013–15, 2017) | | | |
| Nicolás Romero | Chumbicha, Argentina | Minnesota (2025–present) | | | |
| Mauro Rosales | Villa María, Argentina | Vancouver (2014–15, 2017) | Seattle (2011–13), Chivas USA (2014), Dallas (2016) | | |
| Silvio Rudman | Buenos Aires, Argentina | Columbus (1997) | | | |
| Pablo Ruíz | Comodoro Rivadavia, Argentina | Salt Lake (2017–18, 2020–present) | | | |
| Darío Sala | Córdoba, Argentina | Dallas (2005–10) | | | |
| Matías Sánchez | Temperley, Argentina | Columbus (2013) | | | |
| Martin Šarić | Buenos Aires, Argentina | Toronto (2010) | | | |
| Gastón Sauro | Rosario, Argentina | Columbus (2015–16, 2018–19) | | | |
| Rodrigo Schlegel | Remedios de Escalada, Argentina | Orlando (2020–25) | | | |
| Mateo Silvetti | Rosario, Argentina | Inter Miami (2025–present) | | | |
| Luis Solignac | Buenos Aires, Argentina | Chicago (2016–18) | Colorado (2015–16) | | |
| Diego Soñora | Buenos Aires, Argentina | Tampa Bay (2001) | Dallas (1996–97), MetroStars (1998), D.C. United (1999) | | |
| Santiago Sosa | La Plata, Argentina | Atlanta (2021–23) | | | |
| Leonardo Squadrone | La Plata, Argentina | New England (1997) | | | |
| Nicolás Stefanelli | Quilmes, Argentina | Inter Miami (2023) | | | |
| Joaquín Torres | Neuquén, Argentina | Philadelphia (2023–24) | Montreal (2021–22) | | |
| Maximiliano Urruti | Rosario, Argentina | New England (2025) | Toronto (2013), Portland (2013–15), Dallas (2016–18), Montreal (2019–20), Houston (2021), Austin (2022–23) | | |
| Oscar Ustari | América, Argentina | Inter Miami (2024–25) | | | |
| Milton Valenzuela | Rosario, Argentina | Columbus (2018, 2020–21) | | | |
| Diego Valeri | Lanús, Argentina | Portland (2013–21) | | | |
| Jorge Vázquez | Buenos Aires, Argentina | New England (2003) | | | |
| Daniel Vega | Cutral Có, Argentina | San Jose (2019–21) | | | |
| Alan Velasco | Quilmes, Argentina | Dallas (2022–24) | | | |
| Matías Vera | Merlo, Argentina | Houston (2019–22) | | | |
| Gonzalo Verón | Moreno, Argentina | New York Red Bulls (2015–17) | | | |
| Pablo Vitti | Rosario, Argentina | Toronto (2009) | | | |
| Marcelo Weigandt | Avellaneda, Argentina | Inter Miami (2024–25) | | | |
Bolivia  | Pato Aguilera | Santa Cruz | New England (2001) | Columbus (2000–01) | | |
| Marco Etcheverry | Santa Cruz, Bolivia | D.C. United (1996–2003) | | | |
| José Carlos Fernández | Santa Cruz, Bolivia | New England (2001) | | | |
| Jefferson Gottardi | Santa Cruz, Bolivia | Tampa Bay (1999) | | | |
| Cristhian Machado | Cochabamba, Bolivia | New England (2018) | | | |
| Bruno Miranda | Santa Cruz, Bolivia | D.C. United (2017–18) | | | |
| Efrain Morales | Decatur, US | Montréal (2025–present) | Atlanta (2024–25) | | |
| Jaime Moreno | Santa Cruz, Bolivia | D.C. United (1996–02, 2004–10) | MetroStars (2003–04) | | |
| Juan Manuel Peña | Santa Cruz, Bolivia | D.C. United (2010) | | | |
| Jairo Quinteros | Santa Cruz, Bolivia | Inter Miami (2022) | | | |
| Mauricio Ramos | Santa Cruz, Bolivia | New England (2000) | Tampa Bay (1998–99) | | |
| Maurizio Rocha | Santa Cruz, Bolivia | Miami Fusion (1999–00) | | | |
| Sergio Salas | Cochabamba, Bolivia | D.C. United (2000) | | | |
| Berthy Suárez | Santa Cruz, Bolivia | D.C. United (1996) | | | |
| Joselito Vaca | Santa Cruz, Bolivia | MetroStars (2004) | Dallas (2001–03) | | |
Brazil  | Adaílton | Salvador, Brazil | Chicago (2015) | | | |
| Adauto Neto | Itabuna, Brazil | Dallas (2002) | | | |
| Alex | São Paulo, Brazil | Houston (2015–17) | Chicago (2012–15) | | |
| Alex Cazumba | Amélia Rodrigues, Brazil | LA Galaxy (2010) | | | |
| Alexandre Pato | Pato Branco, Brazil | Orlando (2021–22) | | | |
| Álvaro Augusto | | Dallas (2025–present) | | | |
| Álvaro Pires | Jardinópolis, Brazil | LA Galaxy (2008) | | | |
| Anderson Conceição | Caravelas, Brazil | Philadelphia (2016) | | | |
| Anderson Rosa | | Colorado (2025–present) | | | |
| André Rocha | São Paulo, Brazil | Dallas (2008–09) | | | |
| Andre Shinyashiki | São Paulo, Brazil | Charlotte (2022–23) | Colorado (2019–22) | | |
| Antônio Carlos | Rio de Janeiro, Brazil | Houston (2025–present) | Orlando (2020–23) | | |
| Antony | Curitiba, Brazil | Portland (2023–present) | | | |
| Artur | Brumado, Brazil | Houston (2023–present) | Columbus (2017–22) | | |
| Auro Jr. | Jaú, Brazil | Toronto (2018–21) | | | |
| Branco | Bagé, Brazil | MetroStars (1997) | | | |
| Brenner | Cuiabá, Brazil | Cincinnati (2021–23, 2025) | | | |
| Bressan | Caxias do Sul, Brazil | Dallas (2019–21) | | | |
| Bruno Guarda | Piracicaba, Brazil | Dallas (2008–12) | | | |
| Bruno Menezes | Santos, Brazil | Chicago (2007) | | | |
| Caio Alexandre | Duque de Caxias, Brazil | Vancouver (2021–22) | | | |
| Camilo Sanvezzo | Presidente Prudente, Brazil | Vancouver (2011–13) | | | |
| Casemiro | São José dos Campos, Brazil | Inter Miami (2026–present) | | | |
| Cássio | Rio de Janeiro, Brazil | New England (2005) | | | |
| Catê | Cruz Alta, Brazil | New England (2001) | | | |
| Célio Pompeu | Fortaleza, Brazil | St. Louis (2023–present) | | | |
| Daniel | Barra do Garças, Brazil | Dallas (2026–present) | San Jose (2023–26) | | |
| Danilo Silva | Campinas, Brazil | Los Angeles FC (2018–20) | MetroStars (2005) | | |
| David Lopes | Maringá, Brazil | LA Galaxy (2012) | Chivas USA (2011–12) | | |
| Dejair | Brasília, Brazil | Chivas USA (2008) | | | |
| Denílson | Diadema, Brazil | Dallas (2007) | | | |
| Diego Borges | Agudos, Brazil | Kansas City (2026–present) | | | |
| Diego Walsh | Santos, Brazil | Kansas City (2004–05) | Columbus (2003) | | |
| Douglas Costa | Sapucaia do Sul, Brazil | LA Galaxy (2022–23) | | | |
| Edu | Jaú, Brazil | Colorado (2012) | | | |
| Eduardo | Rio de Janeiro, Brazil | San Jose (2010) | | | |
| Elias Manoel | Campinas, Brazil | New York Red Bulls (2022–24) | | | |
| Erick | Ilha Solteira, Brazil | Dallas (2013) | | | |
| Evander | Rio de Janeiro, Brazil | Cincinnati (2025–present) | Portland (2023–24) | | |
| Everton Luiz | Porto Alegre, Brazil | Salt Lake (2019–22) | | | |
| Fabinho | Ariquemes, Brazil | Philadelphia (2013–19) | | | |
| Fábio | São Paulo, Brazil | New York Red Bulls (2021) | | | |
| Felipe Andrade | Boa Viagem, Brazil | Houston (2025–present) | | | |
| Felipe | Engenheiro Beltrão, Brazil | Orlando (2023–24) | Montreal (2012–14), New York Red Bulls (2015–18), Vancouver (2018–19), D.C. United (2019–21), Austin (2022) | | |
| Fernando Bob | Cabo Frio, Brazil | Minnesota (2018) | | | |
| Fred | Belo Horizonte, Brazil | Philadelphia (2014–15) | D.C. United (2007–11) | | |
| Gabriel Pec | Petrópolis, Brazil | LA Galaxy (2024–26) | | | |
| Gabriel Pereira | São Paulo, Brazil | New York City FC (2022–23) | | | |
| Gabriel Pirani | Penápolis, Brazil | San Diego (2026–present) | D.C. United (2023–26) | | |
| Geovane Jesus | Riacho de Santana, Brazil | Dallas (2023) | | | |
| Geovanni | Acaiaca, Brazil | San Jose (2010) | | | |
| Getterson | Engenheiro Beltrão, Brazil | Dallas (2016) | | | |
| Gilberto | Piranhas, Brazil | Chicago (2015–16) | Toronto (2014–15) | | |
| Gilberto Flores | Toledo, Brazil | MetroStars (2004–05) | | | |
| Gilmar | São Paulo, Brazil | MetroStars (2001) | Tampa Bay (1997–98) | | |
| Gláuber | São José do Rio Preto, Brazil | Columbus (2013) | | | |
| Gregore | Juiz de Fora, Brazil | Inter Miami (2021–23) | | | |
| Guido | Ribeirão Preto, Brazil | MetroStars – 1997) | | | |
| Guilherme | São Paulo, Brazil | Houston (2026–present) | | | |
| Guilherme Biro | Curitiba, Brazil | Austin (2024–present) | | | |
| Guly do Prado | Campinas, Brazil | Chicago (2015) | | | |
| Héber | Colorado do Oeste, Brazil | Seattle (2023) | New York City FC (2019–22) | | |
| Iago Teodoro | Volta Redonda | Orlando (2026–present) | | | |
| Ibson | São Gonçalo, Brazil | Minnesota (2017–18) | | | |
| Igor Jesus | Goiânia, Brazil | Los Angeles FC (2025–present) | | | |
| Igor Julião | Rio de Janeiro, Brazil | Kansas City (2014, 2017) | | | |
| Ilsinho | São Bernardo do Campo, Brazil | Philadelphia (2016–21) | | | |
| Jackson | Franca | Toronto (2014–15) | Dallas (2010–13) | | |
| Jailson | Caçapava do Sul, Brazil | Los Angeles FC (2025) | | | |
| Jean Mota | São Paulo, Brazil | Inter Miami (2022–24) | | | |
| Jeanderson | Serra, Brazil | Portland (2015) | | | |
| Jéferson | Brasíilia, Brazil | Kansas City (2011) | | | |
| João Batista | Brazil | Tampa Bay (1997) | | | |
| João Luiz | Brazil | MetroStars (1997) | | | |
| João Paulo | Serafina Corrêa, Brazil | Seattle (2020–25) | | | |
| João Pedro | Indaiatuba, Brazil | Charlotte (2024) | | | |
| João Peglow | Porto Alegre, Brazil | D.C. United (2025–present) | | | |
| Judson | Arês, Brazil | San Jose (2019–23) | | | |
| Júlio Baptista | São Paulo, Brazil | Orlando (2016) | | | |
| Júlio César | São Luís, Brazil | Kansas City (2011–12) | | | |
| Júlio César | Duque de Caxias, Brazil | Toronto (2014) | | | |
| Juninho | São José dos Campos, Brazil | LA Galaxy (2010–15, 2019) | Chicago (2017) | | |
| Juninho | Nova Iguaçu, Brazil | Orlando (2023) | | | |
| Juninho Pernambucano | Recife, Brazil | New York Red Bulls (2013) | | | |
| Júnior Carreiro | Belo Horizonte, Brazil | D.C. United (2010) | | | |
| Júnior Urso | Taboão da Serra, Brazil | Houston (2025) | Orlando (2020–23), Charlotte (2024) | | |
| Kaick | Rio de Janeiro, Brazil | Dallas (2025–present) | | | |
| Kaká | Gama, Brazil | Orlando (2015–17) | | | |
| Klauss | Criciúma, Brazil | LA Galaxy (2026–present) | St. Louis (2023–25) | | |
| Kléberson | Uraí, Brazil | Philadelphia (2013) | | | |
| Leo Afonso | São Paulo, Brazil | Atlanta (2025) | Inter Miami (2024–25) | | |
| Léo Chú | Porto Alegre, Brazil | Dallas (2025) | Seattle (2021–24) | | |
| Leo Fernandes | São Paulo, Brazil | Philadelphia (2013–14, 2016) | | | |
| Léo Pereira | Curitiba, Brazil | Orlando (2017) | | | |
| Leonardo | São Paulo, Brazil | Houston (2013–18) | LA Galaxy (2010–11) | | |
| Lineker Rodrigues | | Salt Lake (2026–present) | | | |
| Lucas Calegari | Cuiabá, Brazil | LA Galaxy (2023) | | | |
| Lucas Esteves | São Paulo, Brazil | Colorado (2021–22) | | | |
| Lucas Halter | Salto, Brazil | Houston (2026–present) | | | |
| Lucas Venuto | Governador Valadares, Brazil | Vancouver (2019) | | | |
| Luciano Emílio | Ilha Solteira, Brazil | D.C. United (2007–10) | | | |
| Luighi | São Paulo, Brazil | New York City FC (2026–present) | | | |
| Luis Otávio | Beberibe, Brazil | Orlando (2026–present) | | | |
| Luiz Araújo | Taquaritinga, Brazil | Atlanta (2021–23) | | | |
| Luiz Camargo | Vinhedo, Brazil | Houston (2011–13) | | | |
| Luquinhas | Ceilândia, Brazil | New York Red Bulls (2022–23) | | | |
| Maciel | Rio de Janeiro, Brazil | New England (2021–22) | | | |
| Maicon Santos | Paracambi, Brazil | Chicago (2013) | Chivas USA (2009–10), Toronto (2010–11), Dallas (2011), D.C. United (2012) | | |
| Marcelo | São Carlos, Brazil | Chicago (2019) | | | |
| Marcelo Saragosa | Campo Grande, Brazil | D.C. United (2012–13) | LA Galaxy (2004–06), Dallas (2006–09) Chivas USA (2009–10) | | |
| Marcelo Sarvas | São Paulo, Brazil | D.C. United (2016–17) | LA Galaxy (2012–14), Colorado (2015) | | |
| Marcos Dias | Formoso do Araguaia, Brazil | New England (2024) | | | |
| Marquinho | Porto Alegre, Brazil | Colorado (1998) | | | |
| Marlon | Duque de Caxias, Brazil | Los Angeles FC (2024–25) | | | |
| Marquinhos Pedroso | Tubarão, Brazil | D.C. United (2019) | Dallas (2018–19) | | |
| Mateus Jordão Costa | | Salt Lake (2010-2013) | | | |
| Matheus Aiás | Palmares Paulista, Brazil | Orlando (2020–21) | | | |
| Matheus Davó | São Paulo, Brazil | Philadelphia (2021) | | | |
| Matheus Nascimento | Niterói, Brazil | LA Galaxy (2025–present) | | | |
| Matheus Pereira | São Paulo, Brazil | Toronto (2026–present) | | | |
| Matheus Rossetto | Santo Amaro da Imperatriz, Brazil | Atlanta (2020–23) | | | |
| Matheus Silva | Taboão da Serra, Brazil | San Jose (2016) | | | |
| Max | Juiz de Fora, Brazil | Colorado (2022–23) | | | |
| Maximiniano | Rio de Janeiro, Brazil | Minnesota (2018) | | | |
| Micael | Presidente Prudente, Brazil | Inter Miami (2026–) | Houston (2022–24) | | |
| Michel | Vitória, Brazil | Dallas (2013–15) | | | |
| Naldo | Rio de Janeiro, Brazil | LA Galaxy (2005–06) | | | |
| Nathan | São Paulo, Brazil | Seattle (2024) | San Jose (2021–22) | | |
| Nathan Fogaça | Palmeira, Brazil | Portland (2022–24) | | | |
| Nicolas Firmino | Mantena, Brazil | Atlanta (2023–24) | | | |
| Paulinho McLaren | Igaraçu do Tietê, Brazil | Miami Fusion (1998) | | | |
| Pablo Campos | São Paulo, Brazil | Salt Lake (2009–10) | San Jose (2009) | | |
| Paulo Jr. | Teresina, Brazil | Salt Lake (2010–12) | | | |
| Paulo Nagamura | São Paulo, Brazil | Kansas City (2012–16) | LA Galaxy (2005–06), Toronto (2007), Chivas USA (2007–09, 2010–11) | | |
| PC | São Paulo, Brazil | Vancouver (2019) | Orlando (2017–18) | | |
| Pecka | Rio de Janeiro, Brazil | Salt Lake (2015) | | | |
| Pedrinho | Rio de Janeiro, Brazil | Dallas (2025) | | | |
| Pedro Leão | | Orlando (2026–present) | | | |
| Pedro Ribeiro | Belo Horizonte, Brazil | Orlando (2015–16) | Philadelphia (2014) | | |
| Phelipe Megiolaro | Campinas, Brazil | Dallas (2020–21) | | | |
| Rafael | Água Boa, Brazil | D.C. United (2013) | | | |
| Rafael Cabral | Sorocaba, Brazil | Salt Lake (2025–present) | | | |
| Rafael Gomes | Rio de Janeiro, Brazil | Colorado (2008) | | | |
| Rafael Navarro | Cabo Frio, Brazil | Colorado (2023–present) | | | |
| Rafael Santos | Londrina, Brazil | St. Louis (2026–present) | Orlando (2023–25), Colorado (2025) | | |
| Ramiro | Gramado, Brazil | Dallas (2025–present) | | | |
| Raphael Augusto | Rio de Janeiro, Brazil | D.C. United (2013) | | | |
| Raul Gustavo | Pedro Leopoldo, Brazil | New York City FC (2025–present) | | | |
| Ricardinho | Sinop, Brazil | Dallas (2007–08) | | | |
| Ricardo Villar | São Paulo, Brazil | Dallas (2011–12) | | | |
| Ricardo Virtuoso | Guarapuava, Brazil | Columbus (2006–07) | | | |
| Roberto Gaúcho | Santa Rosa, Brazil | Miami Fusion (1999) | | | |
| Roberto Linck | Cachoeira do Sul, Brazil | New England (2010) | | | |
| Robinho | Senador Pompeu, Brazil | Orlando (2019–20) | Columbus (2019) | | |
| Rodrigo Faria | Rio de Janeiro, Brazil | MetroStars, Chicago, San Jose (2001–03) | | | |
| Rodrigo Ramos | Juazeiro, Brazil | Chicago (2016) | | | |
| Rodrigues | Arês, Brazil | San Jose (2022–25) | | | |
| Ruan | Rio de Janeiro, Brazil | Dallas (2024) | Orlando (2019–22), D.C. United (2023), Montréal (2024) | | |
| Rwan Cruz | Jaboatão dos Guararapes, Brazil | Salt Lake (2025) | | | |
| Samuel | São Borja, Brazil | LA Galaxy (2014) | | | |
| Sérgio Santos | Belo Horizonte, Brazil | Atlanta (2026–present) | Philadelphia (2019–22), Cincinnati (2022–25), Houston (2025) | | |
| Stefani Miglioranzi | Poços de Caldas, Brazil | Philadelphia (2010–11) | LA Galaxy (2006, 2009), Columbus (2007–08) | | |
| Stefano Pinho | São João Nepomuceno, Brazil | Orlando (2018) | | | |
| Talles Magno | Rio de Janeiro, Brazil | New York City FC (2021–24, 2026–present) | | | |
| Thiago | Porto Alegre, Brazil | Chicago (2005–07) | | | |
| Thiago | Brazil | LA Galaxy (2006) | | | |
| Thiago Andrade | Araras, Brazil | New York City FC (2021–23) | | | |
| Thiago Fernandes | Recife, Brazil | Houston (2022) | | | |
| Thiago Martins | São Paulo, Brazil | Colorado (2006) | D.C. United (2003), Chivas USA (2005), New York Red Bulls (2006) | | |
| Thiago Martins | São João Evangelista, Brazil | New York City FC (2022–present) | | | |
| Thiago Santos | Curitiba, Brazil | Dallas (2020) | | | |
| Tiago | Ipirá, Brazil | Orlando (2026–present) | | | |
| Thomás | Juiz de Fora, Brazil | Seattle (2015) | | | |
| Vinicius Mello | Sapucaia do Sul, Brazil | Charlotte (2023) | | | |
| Vítor Costa | Valente, Brazil | San Jose (2024–present) | | | |
| Wélton | Cambuci, Brazil | Miami Fusion (1999–00) | New England (1996), LA Galaxy (1997–98) | | |
| William Oliveira | São Paulo, Brazil | Chicago (2007) | | | |
| Zeca | Paranavaí, Brazil | Houston (2022) | | | |
| Zico | | San Jose (1997) | | | |
Chile  | Miguel Aceval | Santiago, Chile | Toronto (2012) | | | |
| Pablo Aránguiz | Independencia, Chile | Dallas (2018–19) | | | |
| Alexander Aravena | Huechuraba, Chile | Portland (2026–present) | | | |
| José Bizama | Curanilahue, Chile | Houston (2019–21) | | | |
| Carlos Carmona | Coquimbo, Chile | Atlanta (2017) | | | |
| Paulo Díaz | Santa Cruz, Chile | Atlanta (2026–present) | | | |
| Carlos Farias | Santiago, Chile | San Jose (1999) | | | |
| Thomas Gillier | Las Condes, Chile | Montréal (2025–present) | | | |
| Marcos González | Rio de Janeiro, Brazil | Columbus (2006–07) | | | |
| Felipe Gutiérrez | Quintero, Chile | Colorado (2022–23) | Kansas City (2018–19) | | |
| Kevin Harbottle | Antofagasta, Chile | Colorado (2013) | | | |
| Pablo Hernández | Tucumán, Argentina | D.C. United (2010) | | | |
| Benjamín Kuscevic | Santiago, Chile | Toronto (2026–present) | | | |
| Favian Loyola | Camp Lejeune, US | Orlando (2023) | | Capped for the US men's national U17 and U19 teams | |
| Luis Marín | Valparaíso, Chile | Kansas City (2015) | | | |
| Victor Mella | Santiago, Chile | New England (1998) | San Jose (1996) | | |
| Sebastián Miranda | Las Condes, Chile | Columbus (2011–12) | | | |
| Milovan Mirošević | Santiago, Chile | Columbus (2012) | | | |
| Felipe Mora | Santiago, Chile | Portland (2020–26) | | | |
| Marcelo Morales | Santiago, Chile | New York Red Bulls (2025) | | | |
| Pedro Morales | Hualpén, Chile | Vancouver (2014–16) | | | |
| Raúl Palacios | Los Andes, Chile | Colorado (2002) | | | |
| Martín Rodríguez | Diego de Almagro, Chile | D.C. United (2022, 2024) | | | |
| Sebastián Rozental | Santiago, Chile | Columbus (2006) | | | |
| Diego Rubio | Santiago, Chile | Austin (2024–25) | Kansas City (2016–18), Colorado (2019–23) | | |
| Alexis Sánchez | Tocopilla, Chile | Montréal (2026–present) | | | |
| Jeisson Vargas | Recoleta, Chile | Montreal (2018) | | | |
| Marcelo Vega | Copiapó, Chile | MetroStars (1998) | | | |
Colombia  | Abel Aguilar | Bogotá, Colombia | Dallas (2018) | | | |
| Fernando Álvarez | New York City, US | Montréal (2023–25) | | Capped for Mexico's U16 and U18 football teams | |
| Leonel Álvarez | Remedios, Colombia | New England (1999–01) | Dallas (1996, 1998–99) | | |
| Pedro Álvarez | Itagüí, Colombia | MetroStars (2001) | | | |
| Steven Alzate | Camden, England | Atlanta (2025–present) | | | |
| Rafael Amaya | Bogotá, Colombia | Colorado (1997) | San Jose (1996) | | |
| Juan Pablo Ángel | Medellín, Colombia | Chivas USA (2011–12) | New York Red Bulls (2007–10), LA Galaxy (2011) | | |
| Tomás Ángel | Birmingham, England | San Diego (2025–26) | Los Angeles FC (2024) | | |
| Iván Angulo | Tumaco, Colombia | Orlando (2022–present) | | | |
| Cristian Arango | Medellín, Colombia | San Jose (2025) | Los Angeles FC (2021–22), Salt Lake (2023–24) | | |
| Victor Arboleda | El Cerrito, Colombia | Portland (2017–18) | | | |
| Yair Arboleda | Tuluá, Colombia | Houston (2016) | | | |
| Juan José Arias | | Salt Lake (2026–present) | | | |
| Santiago Arias | Medellín, Colombia | Cincinnati (2023) | | | |
| Emilio Aristizábal | | Toronto (2026–present) | | | |
| Jhonny Arteaga | Cali, Colombia | New York Red Bulls (2012) | | | |
| Dairon Asprilla | Istmina, Colombia | Portland (2015–24) | | | |
| Eduard Atuesta | Vélez, Colombia | Orlando (2024–present) | Los Angeles FC (2018–21) | | |
| Michael Barrios | Barranquilla, Colombia | LA Galaxy (2023) | Dallas (2015–20), Colorado (2021–23) | | |
| Andy Batioja | | Houston (2025–present) | | | |
| Julián Bazán | Pereira, Colombia | New York Red Bulls (2026–present) | | | |
| Daniel Bedoya | Medellín, Colombia | New York City FC (2019) | | | |
| Jair Benítez | Jamundí, Colombia | Dallas (2009–14) | | | |
| Dylan Borrero | Palmira, Colombia | New England (2022–24) | | | |
| Michael Bustamante | Medellín, Colombia | New York Red Bulls (2014) | | | |
| Juan David Cabezas | Cali, Colombia | Houston (2017–19) | | | |
| Jorge Cabezas Hurtado | Tumaco, Colombia | New York Red Bulls (2023) | | | |
| Déiber Caicedo | Barbacoas, Colombia | Vancouver (2021–24) | | | |
| Juan Caicedo | Carepa, Colombia | New England (2019) | | | |
| José Caicedo | Palmira, Colombia | Portland (2026–present) | | | |
| Luis Caicedo | Apartadó, Colombia | Houston (2023) | New England (2018–19, 2021) | | |
| Javier Calle | Medellín, Colombia | New York City FC (2015) | | | |
| Fernando Cárdenas | Cartago, Colombia | New England (2012) | | | |
| Juan Castilla | Cali, Colombia | Houston (2021) | | | |
| Fabián Castillo | Cali, Colombia | Dallas (2011–16) | | | |
| Jaime Castrillón | Puerto Nare, Colombia | Colorado (2012–13) | | | |
| Brayan Ceballos | Cali, Colombia | Montréal (2026–present) | New England (2025–26) | | |
| Diego Chará | Cali, Colombia | Portland (2011–present) | | | |
| Yimmi Chará | Cali, Colombia | Portland (2020–23) | | | |
| Alex Comas | Barranquilla, Colombia | MetroStars (2000–01) | | | |
| Wilman Conde | Cali, Colombia | New York Red Bulls (2012) | Chicago (2007–10) | | |
| José Erick Correa | Acandí, Colombia | Chivas USA (2012–13) | | | |
| Daniel Cruz | Cali, Colombia | Dallas (2011) | | | |
| Yamith Cuesta | Turbo, Colombia | Chicago (2011) | Chivas USA (2009–10) | | |
| Cristian Dájome | Bogotá, Colombia | D.C. United (2023–24) | Vancouver (2020–23) | | |
| Antony de Ávila | Santa Marta, Colombia | MetroStars (1996–97) | | | |
| Jefferson Díaz | San Andrés, Colombia | Minnesota (2024–present) | | | |
| Jhon Durán | Zaragoza, Colombia | Chicago (2022) | | | |
| Oscar Echeverry | Cali, Colombia | New York Red Bulls (2008) | | | |
| Andrés Escobar | Puerto Tejada, Colombia | Dallas (2014) | | | |
| Pablo Escobar | Florida, Colombia | Kansas City (2010) | | | |
| David Ferreira | Santa Marta, Colombia | Dallas (2009–13) | | | |
| Jimer Fory | Santander de Quilichao, Colombia | Portland (2025–present) | | | |
| Carlos Garcés | López de Micay, Colombia | LA Galaxy (2024–present) | | | |
| Mender García | Tumaco, Colombia | Minnesota (2022–23) | | | |
| Olmes García | Barranquilla, Colombia | Salt Lake (2013–16) | | | |
| Andrés Gómez | Quibdó, Colombia | Salt Lake (2023–24) | | | |
| Yeimar Gómez | Tadó, Colombia | Seattle (2020–present) | | | |
| Juan Diego González | Medellín, Colombia | Philadelphia (2010) | | | |
| Mauricio González | | Minnesota (2026–present) | | | |
| Yony González | Medellín, Colombia | LA Galaxy (2020) | | | |
| Hárrison Henao | Bello, Colombia | Colorado (2012) | | | |
| Cucho Hernández | Pereira, Colombia | Columbus (2022–24) | | | |
| Rubén Darío Hernández | Armenia, Colombia | MetroStars (1996) | | | |
| Sergio Herrera | Barrancabermeja, Colombia | Columbus (2010) | | | |
| Cristian Higuita | Cali, Colombia | Orlando (2015–19) | | | |
| Marino Hinestroza | Cali, Colombia | Columbus (2024) | | | |
| Jhon Kennedy Hurtado | Palmira, Colombia | Chivas USA (2014) | Seattle (2009–13), Chicago (2014) | | |
| Carlos Lizarazo | Cali, Colombia | Dallas (2016) | | | |
| John Lozano | Guacarí, Colombia | New England (2012) | | | |
| Christian Mafla | Palmira, Colombia | New England (2021) | | | |
| Mauro Manotas | Sabanalarga, Colombia | Houston (2015–20) | | | |
| Alexis Manyoma | Puerto Tejada, Colombia | Colorado (2025–present) | | | |
| Geiner Martínez | | Philadelphia (2026–present) | | | |
| Gonzalo Martínez | Candelaria, Colombia | D.C. United (2008) | | | |
| Jimmy Medranda | Mosquera, Colombia | Columbus (2023) | Kansas City (2013–19), Nashville (2020), Seattle (2020–22) | | |
| Jefferson Mena | Apartado, Colombia | New York City FC (2015–16) | | | |
| Stiven Mendoza | Palmira, Colombia | New York City FC (2016) | | | |
| Germán Mera | Cali, Colombia | Colorado (2013) | | | |
| Juan José Mina | Guachené, Colombia | New York Red Bulls (2026–) | | | |
| Faryd Mondragón | Cali, Colombia | Philadelphia (2011) | | | |
| Miguel Montaño | Palmira, Colombia | Montreal (2011–12) | Seattle (2010–11) | | |
| Fredy Montero | Campo de la Cruz, Colombia | Seattle (2009–12, 2017, 2021–23) | Vancouver (2019–20) | | |
| Pepe Moreno | Santander de Quilichao, Colombia | New England (2012) | | | |
| Santiago Moreno | Cali, Colombia | Dallas (2026–) | Portland (2021–25) | | |
| Tressor Moreno | Riosucio, Colombia | San Jose (2012) | | | |
| Edwin Mosquera | Quibdó, Colombia | Atlanta (2022–25) | | | |
| Hanyer Mosquera | Istmina, Colombia | Portland (2012) | | | |
| Juan Mosquera | Cali, Colombia | Portland (2022–present) | | | |
| Moisés Mosquera | Medellín, Colombia | Kansas City (2026–present) | | | |
| Santiago Mosquera | Buenaventura, Colombia | Dallas (2018–20) | | | |
| Yerson Mosquera | Apartadó, Colombia | Cincinnati (2023) | | | |
| José Mulato | Cali, Colombia | Dallas (2023) | | | |
| Luis Muriel | Santo Tomás, Colombia | Orlando (2024–25) | | | |
| Jesús Murillo | Cali, Colombia | Los Angeles FC (2020–24) | | | |
| Cristian Nazarit | Villarrica, Colombia | Chicago (2011) | | | |
| Jáder Obrian | María La Baja, Colombia | Austin (2024–25) | Dallas (2021–23) | | |
| Édier Ocampo | Tumaco, Colombia | Vancouver (2024–present) | | | |
| Jámison Olave | Medellín, Colombia | Salt Lake (2008–12, 2015–16) | New York Red Bulls (2013–14) | | |
| Juan Esteban Ortiz | Medellín, Colombia | Dallas (2016) | | | |
| Pablo Ortiz | Tumaco, Colombia | Houston (2025–present) | | | |
| Lionard Pajoy | Villa del Rosario, Colombia | D.C. United (2012–13) | Philadelphia (2012) | | |
| Nelson Palacio | Apartadó, Colombia | Salt Lake (2023–present) | | | |
| Arley Palacios | Chigorodó, Colombia | Miami Fusion (1999) | MetroStars (1998–99) | | |
| Jeisson Palacios | Carepa, Colombia | Nashville (2025–present) | | | |
| Óscar Pareja | Medellín, Colombia | Dallas (1998–05) | New England (1998) | | |
| Santiago Patiño | Medellín, Colombia | Orlando (2019–20) | | | |
| Luis Perea | Medellín, Colombia | Dallas (2012) | | | |
| John Wilmar Pérez | Medellín, Colombia | Columbus (2000–02) | | | |
| Jorge Perlaza | Guapi, Colombia | Philadelphia (2012) | Portland (2011–12) | | |
| Hernán Pertúz | Barranquilla, Colombia | Dallas (2012) | | | |
| Nelson Quiñónes | Tumaco, Colombia | Houston (2022–23, 2025–present) | | | |
| Darwin Quintero | Tumaco, Colombia | Houston (2020–22) | Minnesota (2018–19) | | |
| Wálter Restrepo | San Diego, US | Philadelphia (2016) | | | |
| Andrés Reyes | Puerto Tejada, Colombia | San Diego (2025) | Inter Miami (2020), New York Red Bulls (2021–24) | | |
| Andrés Ricaurte | Medellín, Colombia | Dallas (2020–21) | | | |
| Carlos Rivas | Jamundí, Colombia | New York Red Bulls (2018–19) | Orlando (2015–17) | | |
| Nelson Rivas | Pradera, Colombia | Montreal (2012) | | | |
| Rafael Robayo | Bogotá, Colombia | Chicago (2012) | | | |
| Ángelo Rodríguez | San Andrés Island, Colombia | Minnesota (2018–19) | | | |
| Emerson Rodríguez | Buenaventura, Colombia | Inter Miami (2022) | | | |
| James Rodríguez | Cúcuta, Colombia | Minnesota (2026) | | | |
| Milton Rodríguez | Cali, Colombia | Dallas (2010–11) | | | |
| Nicolás Rodríguez | San José del Guaviare, Colombia | Orlando (2025) | | | |
| Jhohan Romaña | Apartadó, Colombia | Austin (2021–22) | | | |
| Daniel Rosero | Bogotá, Colombia | Kansas City (2023–25) | | | |
| Eddie Segura | Pereira, Colombia | Los Angeles FC (2019–22, 2024–present) | | | |
| Diego Serna | Medellín, Colombia | Colorado (2005) | Miami Fusion (1998–01), MetroStars (2002), New England (2002–03), LA Galaxy (2003) | | |
| Carlos Terán | Turbo, Colombia | Chicago (2020–25) | | | |
| Juan Toja | Bogotá, Colombia | New England (2012–13) | Dallas (2007–08) | | |
| Róger Torres | Barrancabermeja, Colombia | Philadelphia (2010–13) | | | |
| John Jairo Tréllez | Turbo, Colombia | Dallas (1999) | | | |
| Iván Trujillo | Santander de Quilichao, Colombia | Kansas City (2008) | | | |
| Carlos Valderrama | Santa Marta, Colombia | Colorado (2001–02) | Tampa Bay (1996–97, 1999–01), Miami Fusion (1997–99) | | |
| Carlos Valdés | Cali, Colombia | Philadelphia (2011–12, 2014) | | | |
| Adolfo Valencia | Buenaventura, Colombia | MetroStars (2000–01) | | | |
| Jhojan Valencia | Cali, Colombia | Austin (2022–24) | | | |
| John Valencia | Medellín, Colombia | Chivas USA (2012) | | | |
| José Adolfo Valencia | Bogotá, Colombia | Portland (2013) | | | |
| Kerwin Vargas | Concordia, Colombia | Charlotte (2022–26) | | | |
| Sebastián Velásquez | Medellín, Colombia | New York City FC (2015) | Salt Lake (2012–14) | | |
| Brayan Vera | San Luis, Colombia | Montréal (2026–present) | Salt Lake (2023–25) | | |
| Henry Zambrano | Soledad, Colombia | D.C. United (2002) | MetroStars (1999), Colorado (2000) | | |
| Luis Zapata | Cali, Colombia | Colorado (2012) | | | |
Ecuador  | Jordy Alcívar | Manta, Ecuador | Charlotte (2022) | | | |
| Alexander Alvarado | Quevedo, Ecuador | Orlando (2020–21) | | | |
| Juan Luis Anangonó | Ibarra, Ecuador | Chicago (2013–14) | | | |
| Marco Angulo | Esmeraldas, Ecuador | Cincinnati (2023) | | | |
| Xavier Arreaga | Guayaquil, Ecuador | New England (2024) | Seattle (2019–24) | | |
| Dixon Arroyo | Guayaquil, Ecuador | Inter Miami (2023) | | | |
| Luis Bolaños | Quito, Ecuador | Chivas USA (2014) | | | |
| Miller Bolaños | Esmeraldas, Ecuador | Chivas USA (2012–13) | | | |
| Félix Borja | San Lorenzo, Ecuador | Chivas USA (2014) | | | |
| Bruno Caicedo | Esmeraldas Province, Ecuador | Vancouver (2026–present) | | | |
| Fricio Caicedo | | Inter Miami (2026–present) | | | |
| Diego Calderón | Quito, Ecuador | Colorado (2013) | | | |
| Leonardo Campana | Guayaquil, Ecuador | New England (2025–present) | Inter Miami (2022–24) | | |
| José Cifuentes | Esmeraldas, Ecuador | Toronto (2025–present) | Los Angeles FC (2020–23) | | |
| Washington Corozo | Guayaquil, Ecuador | Austin (2022) | | | |
| Patrickson Delgado | Ibarra, Ecuador | Dallas (2024–present) | | | |
| Jhon Espinoza | Guayaquil, Ecuador | Chicago (2021–22) | | | |
| Michael Estrada | Guayaquil, Ecuador | D.C. United (2022) | | | |
| Víctor Estupiñán | Quinindé, Ecuador | Chivas USA (2011) | | | |
| Alan Franco | Jujan, Ecuador | Charlotte (2022) | | | |
| Ariel Graziani | Empalme Villa Constitución, Ecuador | San Jose (2002) | New England (1998), Dallas (1999, 2000–2001) | | |
| Carlos Gruezo | Santo Domingo, Ecuador | San Jose (2023–24) | Dallas (2016–19) | | |
| Eduardo Hurtado | Esmeraldas, Ecuador | New England (2000) | LA Galaxy (1996–98), MetroStars (1998–99) | | |
| Romario Ibarra | Atuntaqui, Ecuador | Minnesota (2018–19) | | | |
| Anderson Julio | Pimampiro, Ecuador | Dallas (2025–present) | Salt Lake (2021–24) | | |
| Fausto Klinger | | MetroStars (2001) | | | |
| Martin Klinger | Cuenca, Ecuador | MetroStars (2001) | | | |
| Sebas Méndez | Mira, Ecuador | Los Angeles FC (2022) | Orlando (2019–22) | | |
| Roberto Miña | Guayaquil, Ecuador | Dallas (2006–07) | | | |
| Oswaldo Minda | Pasaje, Ecuador | Chivas USA (2012–14) | | | |
| Allen Obando | Quito, Ecuador | Inter Miami (2025) | | | |
| Joao Ortiz | Esmeraldas, Ecuador | Portland (2025–present) | | | |
| Diego Palacios | Guayaquil, Ecuador | Los Angeles FC (2019–23) | | | |
| Cristian Penilla | Esmeraldas, Ecuador | New England (2018–20) | | | |
| Joao Plata | Guayaquil, Ecuador | Salt Lake (2013–19) | Toronto (2011–2012) | | |
| Joshué Quiñónez | Guayaquil, Ecuador | Dallas (2022) | | | |
| Bryan Ramírez | | Cincinnati (2026–present) | | | |
| Wellington Sánchez | Ambato, Ecuador | LA Galaxy (1998) | MetroStars (1998) | | |
| Gustavo Vallecilla | Esmeraldas, Ecuador | Columbus (2023) | Cincinnati (2021–22), Colorado (2022–23) | | |
| Jefferson Valverde | Guayaquil, Ecuador | Houston (2024) | | | |
| Pedro Vite | Babahoyo, Ecuador | Vancouver (2022–25) | | | |
| Edmundo Zura | Pimampiro, Ecuador | San Jose (2011) | | | |
Paraguay  | Miguel Almirón | San Pablo, Paraguay | Atlanta (2017–18, 2025–present) | | | |
| Júnior Alonso | Asunción, Paraguay | Atlanta (2026–present) | | | |
| Luis Amarilla | Asunción, Paraguay | Minnesota (2020, 2022–23) | | | |
| Pedro Báez | Areguá, Paraguay | Salt Lake (2016) | | | |
| Alan Benítez | San Estanislao, Paraguay | Minnesota (2022) | | | |
| Cristian Colmán | San Cosme y Damián, Paraguay | Dallas (2017–18) | | | |
| Josué Colmán | Asunción, Paraguay | Orlando (2018–19) | | | |
| Carlos Coronel | Porto Murtinho, Brazil | New York Red Bulls (2021–25) | Philadelphia (2019) | | |
| Andrés Cubas | Aristóbulo del Valle, Argentina | Vancouver (2022–present) | | Capped for Argentina's national U20 football team | |
| Cecilio Domínguez | Asunción, Paraguay | Austin (2021–22) | | | |
| Sebastián Ferreira | Asunción, Paraguay | Houston (2022–24) | | | |
| Gilberto Flores | Asunción, Paraguay | Cincinnati (2025–26) | | | |
| Iván Franco | Ybycuí, Paraguay | Houston (2023) | | | |
| Matías Galarza | Asunción, Paraguay | Atlanta (2026–present) | | | |
| Gastón Giménez | Formosa, Argentina | Chicago (2020–24) | | Capped for the Argentina national football team | |
| Diego Gómez | San Juan Bautista, Paraguay | Inter Miami (2023–24) | | | |
| Kaku | Ciudadela, Argentina | New York Red Bulls (2018–20) | | Capped for Argentina's national U20 football team | |
| Jerry Laterza | Los Angeles, US | LA Galaxy (1997) | | | |
| Erik López | Asunción, Paraguay | Atlanta (2021, 2023) | | | |
| Líder Mármol | Juan León Mallorquín, Paraguay | Chicago (2008) | | | |
| David Martínez | Buenos Aires, Argentina | Inter Miami (2024–present) | | Capped for Argentina's national U17 football team | |
| Jesús Medina | Asunción, Paraguay | New York City FC (2018–21) | | | |
| Jorge Moreira | Villarrica, Paraguay | Portland (2019–20) | | | |
| Braian Ojeda | Itauguá, Paraguay | Orlando (2026–present) | Salt Lake (2022–23) | | |
| Cristhian Paredes | Yaguarón, Paraguay | Portland (2018–25) | | | |
| Rodney Redes | La Colmena, Paraguay | Austin (2021–23) | | | |
| Matías Rojas | Asunción, Paraguay | Portland (2025) | Inter Miami (2024) | | |
| Nelson Valdez | San Joaquín, Paraguay | Seattle (2015–16) | | | |
| Héctor Villalba | Buenos Aires, Argentina | Atlanta (2017–19) | | | |
Peru  | Luis Abram | Lima, Peru | Atlanta (2023–25) | | | |
| José Alegría | Lima, Peru | D.C. United (2001–03) | | | |
| Miguel Araujo | Villa María del Triunfo, Peru | Portland (2023–24) | | | |
| Carlos Ascues | Caracas, Venezuela | Orlando (2018–19) | | | |
| Kenji Cabrera | Shiga, Japan | Vancouver (2025–present) | | | |
| Alexander Callens | Callao, Peru | New York City FC (2017–22) | | | |
| Wilder Cartagena | El Carmen, Peru | Orlando (2022–24, 2026–present) | | | |
| José Carvallo | Lima, Peru | D.C. United (2008) | | | |
| Carlo Chueca | Lima, Peru | Chivas USA (2013) | | | |
| César Pizarro | Chiclayo, Peru | San Jose (2012) | | | |
| Collin Fernandez | Hinsdale, US | Chicago (2015–16) | | Capped for the US men's national U18 and U20 soccer teams | |
| Raúl Fernández | Lima, Peru | Dallas (2013–14) | | | |
| Edison Flores | Comas, Peru | D.C. United (2020–22) | | | |
| Pedro Gallese | Lima, Peru | Orlando (2020–25) | | | |
| Alexi Gómez | Callao, Peru | Minnesota (2018) | | | |
| Marcos López | La Esperanza, Peru | San Jose (2019–22) | | | |
| Andrés Mendoza | Chincha Alta, Peru | Columbus (2010–11) | | | |
| Percy Olivares | Lima, Peru | Dallas (2002) | | | |
| Andy Polo | Lima, Peru | Portland (2018–21) | | | |
| Yordy Reyna | Chiclayo, Peru | Charlotte (2022) | Vancouver (2017–20), D.C. United (2020–21) | | |
| Raúl Ruidíaz | Villa María del Triunfo, Peru | Seattle (2018–24) | | | |
| Waldir Sáenz | Lima, Peru | Colorado (1998) | | | |
| Jerry Tamashiro | Lima, Peru | Miami Fusion (1998) | | | |
| Miguel Trauco | Tarapoto, Peru | San Jose (2022–23) | | | |
| Walter Vílchez | Chiclayo, Peru | Chivas USA (2013) | | | |
| Yoshimar Yotún | Callao, Peru | Orlando (2017–18) | | | |
Uruguay  | Nicolás Acevedo | Montevideo, Uruguay | New York City FC (2020–22) | | | |
| José Aja | Montevideo, Uruguay | Minnesota (2020) | Orlando (2016–17), Vancouver (2018) | | |
| César Araújo | Cerrito, Uruguay | Orlando (2022–25) | | | |
| Joaquín Ardaiz | Salto, Uruguay | Vancouver (2019) | | | |
| Egidio Arévalo | Paysandú, Uruguay | Chicago (2013) | | | |
| Jorge Bava | Montevideo, Uruguay | Chicago (2017) | | | |
| Rodrigo Brasesco | Montevideo, Uruguay | D.C. United (2011) | | | |
| Gastón Brugman | Rosario, Uruguay | Nashville (2025) | LA Galaxy (2022–24) | | |
| Martín Cáceres | Montevideo, Uruguay | LA Galaxy (2022–24) | | | |
| José Cancela | Santa Lucía, Uruguay | Colorado (2007) | New England (2003–06) | | |
| Felipe Carballo | Montevideo, Uruguay | Portland (2025) | New York Red Bulls (2024–25) | | |
| Paolo Cardozo | Montevideo, Uruguay | Chivas USA (2012) | LA Galaxy (2011–12) | | |
| Manuel Castro | Durazno, Uruguay | Atlanta (2020) | | | |
| Thomás Chacón | Palmitas, Uruguay | Minnesota (2019–20) | | | |
| Diego Cháves | Montevideo, Uruguay | Chicago (2011) | | | |
| Matías Cóccaro | Pirarajá, Uruguay | Montréal (2024) | | | |
| Guzmán Corujo | Rodríguez, Uruguay | Charlotte (2022–23) | | | |
| Bruno Damiani | Montevideo, Uruguay | Philadelphia (2025–present) | | | |
| Diego Fagúndez | Montevideo, Uruguay | New England (2011–20, 2026–present) | Austin (2021–23), LA Galaxy (2023–25) | | |
| Maximiliano Falcón | Paysandú, Uruguay | Inter Miami (2025–present) | | | |
| Álvaro Fernández | Villa Soriano, Uruguay | Chicago (2016–17) | Seattle (2010–12) | | |
| Sebastián Fernández | Montevideo, Uruguay | Vancouver (2014) | | | |
| Francisco Ginella | Montevideo, Uruguay | Los Angeles FC (2020–22) | | | |
| Santiago González | Montevideo, Uruguay | Montreal (2014) | | | |
| Mathías Laborda | Fray Bentos, Uruguay | Vancouver (2023–present) | | | |
| Nicolás Lodeiro | Paysandú, Uruguay | Houston (2025) | Seattle (2016–23), Orlando (2024–25) | | |
| Alex Martínez | Montevideo, Uruguay | Kansas City (2014) | | | |
| Enzo Martínez | Montevideo, Uruguay | Colorado (2018) | | | |
| Nicolás Mezquida | Paysandú, Uruguay | Colorado (2019–22) | Vancouver (2014–18) | | |
| Lucas Monzón | Jaguarão, Brazil | New York Red Bulls (2021–22) | | | |
| Martín Morales | Montevideo, Uruguay | Colorado (2005) | | | |
| Cristian Olivera | Montevideo, Uruguay | Los Angeles FC (2023–24) | | | |
| Adrián Paz | Montevideo, Uruguay | Colorado (1997–98) | Columbus (1996) | | |
| Mauricio Pereyra | Montevideo, Uruguay | Orlando (2019–23) | | | |
| Rodrigo Piñeiro | Montevideo, Uruguay | Nashville (2021) | | | |
| Pablo Pintos | Montevideo, Uruguay | San Jose (2014) | | | |
| Diego Polenta | Montevideo, Uruguay | LA Galaxy (2019) | | | |
| Gastón Puerari | Paysandú, Uruguay | Chicago (2011) | | | |
| Federico Puppo | Colonia del Sacramento, Uruguay | Chicago (2012) | | | |
| Yeferson Quintana | Bella Unión, Uruguay | San Jose (2018) | | | |
| Octavio Rivero | Treinta y Tres, Uruguay | Vancouver (2015–16) | | | |
| Brian Rodríguez | Tranqueras, Uruguay | Los Angeles FC (2019–22) | | | |
| Diego Rodríguez | Montevideo, Uruguay | Vancouver (2015) | | | |
| Jonathan Rodríguez | Florida, Uruguay | Portland (2024–present) | | | |
| Santiago Rodríguez | Montevideo, Uruguay | New York City FC (2021–24) | | | |
| Washington Rodríguez | Montevideo, Uruguay | Dallas (1996) | | | |
| Diego Rossi | Montevideo, Uruguay | Columbus (2023–26) | Los Angeles FC (2018–21) | | |
| Juan Manuel Sanabria | Florida, Uruguay | Salt Lake (2026–present) | | | |
| Lucas Sanabria | Florida, Uruguay | LA Galaxy (2025–present) | | | |
| Vicente Sánchez | Montevideo, Uruguay | Houston (2017) | Colorado (2013–15) | | |
| Marcelo Saracchi | Paysandú, Uruguay | Houston (2026–present) | | | |
| Marcelo Silva | Mercedes, Uruguay | Salt Lake (2017–24) | | | |
| Alejandro Silva | Montevideo, Uruguay | Montreal (2018) | | | |
| Joaquín Sosa | Fray Bentos, Uruguay | Montréal (2024) | | | |
| Luis Suárez | Salto, Uruguay | Inter Miami (2024–present) | | | |
| Cristian Techera | Paysandú, Uruguay | Vancouver (2015–18) | | | |
| David Texeira | Salto, Uruguay | Dallas (2014–15) | | | |
| Facundo Torres | Montevideo, Uruguay | Austin (2026–present) | Orlando (2022–24) | | |
| Joaquín Valiente | Colonia Valdense, Uruguay | Dallas (2026–present) | | | |
| Agustín Viana | Chicago, US | Columbus (2013–14) | | | |
| Diego Viera | Montevideo, Uruguay | Tampa Bay (1996) | | | |
Venezuela  | Bernardo Añor | Caracas, Venezuela | Kansas City (2015) | Columbus (2011–14) | | |
| Fernando Aristeguieta | Caracas, Venezuela | Philadelphia (2015) | | | |
| Anthony Blondell | Cumaná, Venezuela | Vancouver (2018) | | | |
| Pablo Bonilla | Acarigua, Venezuela | Portland (2020–23) | | | |
| Jesús Bueno | Barquisimeto, Venezuela | Philadelphia (2021–present) | | | |
| Jhonder Cádiz | Caracas, Venezuela | Nashville (2020–21) | | | |
| Gustavo Caraballo | Valencia, Venezuela | Orlando (2026–present) | | | |
| Wikelman Carmona | Valle de la Pascua, Venezuela | Montréal (2026–present) | New York Red Bulls (2021–26) | | |
| Cristian Cásseres Jr. | Caracas, Venezuela | New York Red Bulls (2018–23) | | | |
| Carlos Cermeño | Maturín, Venezuela | Dallas (2017) | | | |
| Gabriel Cichero | Caracas, Venezuela | New York Red Bulls (2008) | | | |
| Sergio Córdova | Calabozo, Venezuela | St. Louis (2026–present) | Salt Lake (2022), Vancouver (2023) | | |
| Ender Echenique | Maracay, Venezuela | Cincinnati (2025–present) | | | |
| Rolf Feltscher | Bülach, Switzerland | LA Galaxy (2018–20) | | Capped for Switzerland's national U16, U17, U19, U20 and U21 football teams | |
| Alejandro Fuenmayor | Maracaibo, Venezuela | Houston (2018–21) | | | |
| Erickson Gallardo | Barines, Venezuela | Toronto (2019–20) | | | |
| Luis González | Cariaco, Venezuela | Dallas (2017) | | | |
| José Hernández | Caracas, Venezuela | Atlanta (2018) | | | |
| Ronald Hernández | Barinas, Venezuela | Atlanta (2021–present) | | | |
| Yangel Herrera | La Guaira, Venezuela | New York City FC (2017–18) | | | |
| Kevin Kelsy | Valencia, Venezuela | Portland (2025–present) | Cincinnati (2024) | | |
| Christian Makoun | Valencia, Venezuela | New England (2022–23) | Inter Miami (2020–21), Charlotte (2022) | | |
| Giancarlo Maldonado | Caracas, Venezuela | Chivas USA (2010) | | | |
| David Martínez | El Tigre, Venezuela | Los Angeles FC (2024–present) | | | |
| José Andrés Martínez | Maracaibo, Venezuela | Philadelphia (2020–24) | | | |
| Josef Martínez | Valencia, Venezuela | Columbus (2026–present) | Atlanta (2017–22), Inter Miami (2023), Montréal (2024), San Jose (2025) | | |
| Alejandro Moreno | Barquisimeto, Venezuela | Chivas USA (2011–12) | LA Galaxy (2002–04), San Jose (2005), Houston (2006–07), Columbus (2007–09), Philadelphia (2010) | | |
| Júnior Moreno | San Cristóbal, Venezuela | Houston (2024) | D.C. United (2018–21), Cincinnati (2022–23) | | |
| Alberto Munoz | Maracaibo, Venezuela | Tampa Bay (2001) | | | |
| Miguel Navarro | Maracaibo, Venezuela | Colorado (2026–present) | Chicago (2020–23) | | |
| Javier Otero | Cumaná, Venezuela | Orlando (2024–present) | | | |
| Ronaldo Peña | Acarigua, Venezuela | Houston (2018–20) | | | |
| Daniel Pereira | Caracas, Venezuela | Montréal (2026–) | Austin (2021–26) | | |
| Jeizon Ramírez | San Cristóbal, Venezuela | Salt Lake (2020) | | | |
| Emilio Rentería | Caracas, Venezuela | Columbus (2009–12) | | | |
| Gelmin Rivas | Cumaná, Venezuela | D.C. United (2020) | | | |
| Angel Rivillo | Toulouse, France | Dallas (2000) | | | |
| Jorge Rojas | Mérida, Venezuela | New York Red Bulls (2008–09) | | | |
| Rafael Romo | Turén, Venezuela | D.C. United (2022) | | | |
| Giovanni Savarese | Caracas, Venezuela | San Jose (2000) | MetroStars (1996–99), New England (1999) | | |
| Jefferson Savarino | Maracaibo, Venezuela | Salt Lake (2017–19, 2022–23) | | | |
| Telasco Segovia | Barquisimeto, Venezuela | Inter Miami (2025–present) | | | |
| Giovanny Sequera | | Philadelphia (2026–present) | | | |
| Eduardo Sosa | Barinas, Venezuela | Columbus (2018) | | | |
| Yeferson Soteldo | Acarigua, Venezuela | Toronto (2021) | | | |
| Freddy Vargas | Barquisimento, Venezuela | Dallas (2021) | | | |
| Renzo Zambrano | Aragua de Maturín, Venezuela | Portland (2019–21) | | | |