Isopentenyl phosphate kinase

Isopentenyl phosphate kinase
Identifiers
EC no.2.7.4.26
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Isopentenyl phosphate kinase (EC 2.7.4.26) is an enzyme with systematic name ATP:isopentenyl phosphate phosphotransferase.[1] It catalyses the following chemical reaction

2D representation of the chemical structure of Q27133670.
isopentenyl phosphate
 
Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left
ATP
ADP
 
2D representation of the chemical structure of isopentenyl pyrophosphate.
isopentenyl pyrophosphate

The enzyme first characterised from peppermint and Escherichia coli converts isopentenyl phosphate to isopentenyl pyrophosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[2]

This enzyme takes part in a modified mevalonate pathway in Archaea such as Methanocaldococcus jannaschii.[3][4] Its structure has been determined by X-ray crystallography.[5]

References

  1. ↑ Enzyme 2.7.4.26 at KEGG Pathway Database.
  2. ↑ Lange BM, Croteau R (November 1999). "Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13714–9. Bibcode:1999PNAS...9613714L. doi:10.1073/pnas.96.24.13714. PMC 24130. PMID 10570138.
  3. ↑ Grochowski LL, Xu H, White RH (May 2006). "Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate". Journal of Bacteriology. 188 (9): 3192–8. doi:10.1128/JB.188.9.3192-3198.2006. PMC 1447442. PMID 16621811.
  4. ↑ Chen M, Poulter CD (January 2010). "Characterization of thermophilic archaeal isopentenyl phosphate kinases". Biochemistry. 49 (1): 207–17. doi:10.1021/bi9017957. PMC 3856865. PMID 19928876.
  5. ↑ Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD (May 2010). "X-ray structures of isopentenyl phosphate kinase". ACS Chemical Biology. 5 (5): 517–27. doi:10.1021/cb100032g. PMC 2879073. PMID 20402538.
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