Inositol 3-kinase
| Inositol 3-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.64 | ||||||||
| CAS no. | 37278-07-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Inositol 3-kinase (EC 2.7.1.64) is an enzyme that catalyzes the chemical reaction
The enzyme, which is found in plants, animals, and microbes converts myo-inositol to inositol 3-phosphate (1D-myo-inositol 3-phosphate) by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2][3]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:myo-inositol 1-phosphotransferase. Other names in common use include inositol-1-kinase (phosphorylating), myoinositol kinase, and myo-inositol 1-kinase.[4]
References
- ↑ English, Patricia D.; Dietz, Michael; Albersheim, Peter (1966). "Myoinositol Kinase: Partial Purification and Identification of Product". Science. 151 (3707): 198–199. doi:10.1126/science.151.3707.198. PMID 5907906.
- ↑ Loewus, Mary W.; Sasaki, Ken; Leavitt, Alan L.; Munsell, Ling; Sherman, William R.; Loewus, Frank A. (1982). "Enantiomeric Form of myo -Inositol-1-Phosphate Produced by myo -Inositol-1-Phosphate Synthase and myo -Inositol Kinase in Higher Plants". Plant Physiology. 70 (6): 1661–1663. doi:10.1104/pp.70.6.1661. PMC 1065950. PMID 16662739.
- ↑ Stephens, L. R.; Kay, R. R.; Irvine, R. F. (1990). "A myo -inositol d-3 hydroxykinase activity in Dictyostelium". Biochemical Journal. 272 (1): 201–210. doi:10.1042/bj2720201. PMC 1149677. PMID 2176081.
- ↑ Enzyme 2.7.1.64 at KEGG Pathway Database.
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