Hydroxylysine kinase
| Hydroxylysine kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.81 | ||||||||
| CAS no. | 9073-58-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hydroxylysine kinase (EC 2.7.1.81) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from rat liver converts hydroxylysine to 5-phosphonooxy-L-lysine by transferring a phosphate group from the cofactor, guanosine trphosphate (GTP), which is converted to guanosine diphosphate (GDP). The reaction is a step in lysine degradation.[1]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is GTP:5-hydroxy-L-lysine O-phosphotransferase. Other names in common use include hydroxylysine kinase (phosphorylating), and guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase.[2]
References
- ↑ Hiles RA, Henderson LM (1972). "The partial purification and properties of hydroxylysine kinase from rat liver". J. Biol. Chem. 247 (3): 646–51. doi:10.1016/S0021-9258(19)45657-3. PMID 4621658.
- ↑ Enzyme 2.7.1.81 at KEGG Pathway Database.
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