Hydroxyanthraquinone glucosyltransferase
| Hydroxyanthraquinone glucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.181 | ||||||||
| CAS no. | 112198-78-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hydroxyanthraquinone glucosyltransferase (EC 2.4.1.181) is an enzyme that catalyzes the general chemical reaction
- UDP-glucose + a hydroxyanthraquinone UDP + a glucosyloxyanthraquinone
The two substrates of this enzyme characterised from Cinchona succiruba are a hydroxyanthraquinone and UDP-glucose. Its products are the corresponding glucosylated anthraquinone and uridine diphosphate (UDP). For example, emodin, an active component of several plants used in traditional Chinese medicine,[1] is converted to emodin-8-glucoside:[2]
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:hydroxyanthraquinone O-glucosyltransferase. Other names in common use include uridine diphosphoglucose-anthraquinone glucosyltransferase, and anthraquinone-specific glucosyltransferase.[3]
References
- ↑ Tsay HS, Shyur LF, Agrawal DC, Wu YC, Wang SY (3 November 2017). Medicinal Plants – Recent Advances in Research and Development. Singapore: Springer Singapore. p. 339. ISBN 978-981-10-5978-0.
- ↑ Khouri HE, Ibrahim RK (1987). "Purification and some properties of five anthraquinone-specific glucosyltransferases from Cinchona succiruba cell suspension culture". Phytochemistry. 26 (9): 2531–2535. Bibcode:1987PChem..26.2531K. doi:10.1016/S0031-9422(00)83870-4.
- ↑ Enzyme 2.4.1.181 at KEGG Pathway Database.
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