Homoserine O-succinyltransferase
| Homoserine O-succinyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Homoserine O-acetyltransferase dimer, Bacillus cereus | |||||||||
| Identifiers | |||||||||
| EC no. | 2.3.1.46 | ||||||||
| CAS no. | 62213-51-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Homoserine O-succinyltransferase (EC 2.3.1.46) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme characterised from Escherichia coli are homoserine and succinyl-CoA. Its products are O-succinyl-L-homoserine and coenzyme A.[1]
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-homoserine O-succinyltransferase. Other names in common use include homoserine O-transsuccinylase, and homoserine succinyltransferase. It participates in cysteine and methionine metabolism.[2]
Structural studies
As of late 2016, three structures have been solved for this class of enzymes, with PDB accession codes PDB: 2GHR, PDB: 2H2W, and PDB: 2VDJ.
References
- ↑ Rowbury RJ, Woods DD (September 1964). "O-Succinylhomoserine as an Intermediate in the Synthesis of Cystathionine by Escherichia coli". Journal of General Microbiology. 36 (3): 341–58. doi:10.1099/00221287-36-3-341. PMID 14217349.
- ↑ Enzyme 2.3.1.46 at KEGG Pathway Database.