Glycine N-acyltransferase
| Glycine N-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.13 | ||||||||
| CAS no. | 9029-95-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Glycine N-acyltransferase (GLYAT), also known as acyl-CoA:glycine N-acyltransferase (ACGNAT), (EC 2.3.1.13) is an enzyme that catalyzes a general chemical reaction in which glycine is converted to an N-acyl derivative.[1][2]
- glycine + an acyl-CoA N-acylglycine + CoA
For example, glycine reacts with benzoyl-CoA to give hippuric acid:[3]
Benzoic acid is metabolized by butyrate-CoA ligase into the intermediate, benzoyl-CoA, which is then metabolized by glycine N-acyltransferase into hippuric acid.[3]
The enzyme is a transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:glycine N-acyltransferase. Other names in common use include glycine acyltransferase, and glycine-N-acylase.[4]
References
- ↑ Schachter D, Taggart JV (1954). "Glycine N-acylase: purification and properties". J. Biol. Chem. 208 (1): 263–75. doi:10.1016/S0021-9258(18)65643-1. PMID 13174534.
- ↑ Webster LT, Siddiqui UA, Lucas SV, Strong JM, Mieyal JJ (1976). "Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man". J. Biol. Chem. 251 (11): 3352–8. doi:10.1016/S0021-9258(17)33444-0. PMID 931988.
- 1 2 Nandi DL, Lucas SV, Webster LT (1979). "Benzoyl-coenzyme A:glycine N-acyltransferase and phenylacetyl-coenzyme A:glycine N-acyltransferase from bovine liver mitochondria. Purification and characterization". J. Biol. Chem. 254 (15): 7230–7. doi:10.1016/S0021-9258(18)50309-4. PMID 457678.
- ↑ Enzyme 2.3.1.13 at KEGG Pathway Database.
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