Glycerophosphocholine phosphodiesterase
| glycerophosphocholine phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.2 | ||||||||
| CAS no. | 9025-85-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme glycerophosphocholine phosphodiesterase (EC 3.1.4.2) catalyzes the reaction
-3-(phosphonatooxy)propane-1%252C2-diol.svg.png)
The enzyme characterised from bacteria and liver hydrolyses glycerophosphorylcholine to its components (R)-glyceryl 1-phosphate and choline.[1][2][3] Glycerophosphorylcholine is an osmolyte and this enzyme regulates its level.[4] The glycerophosphocholine pathway of which this is a part is implicated in carcinogenesis and tumor progression.[5]
This enzyme is a hydrolase, specifically one acting on phosphoric diester bonds. The systematic name is sn-glycero-3-phosphocholine glycerophosphohydrolase. Other names in common use include glycerophosphinicocholine diesterase, glycerylphosphorylcholinediesterase, sn-glycero-3-phosphorylcholine diesterase, glycerolphosphorylcholine phosphodiesterase, and glycerophosphohydrolase.[6]
See also
- Glycerophosphocholine cholinephosphodiesterase which hydrolyses glycerophosphorylcholine to glycerol and choline phosphate
References
- ↑ Hayaishi O, Kornberg A (1954). "Metabolism of phospholipides by bacterial enzymes". J. Biol. Chem. 206 (2): 647–63. doi:10.1016/S0021-9258(19)50833-X. PMID 13143024.
- ↑ Dawson RMC (1956). "Liver glycerylphosphorylcholine diesterase". Biochem. J. 62 (4): 689–693. doi:10.1042/bj0620689. PMC 1215983. PMID 13315235.
- ↑ Webster GR, Marples EA, Thompson RH (1957). "Glycerylphosphorylcholine diesterase activity in nervous tissue". Biochem. J. 65 (2): 374–377. doi:10.1042/bj0650374. PMC 1199879. PMID 13403918.
- ↑ Gallazzini, Morgan; Ferraris, Joan D.; Burg, Maurice B. (2008). "GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC". Proceedings of the National Academy of Sciences. 105 (31): 11026–11031. doi:10.1073/pnas.0805496105. PMC 2504799. PMID 18667693.
- ↑ Sonkar, Kanchan; Ayyappan, Vinay; Tressler, Caitlin M.; et al. (2019). "Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer". NMR in Biomedicine. 32 (10) e4112. doi:10.1002/nbm.4112. PMC 6803034. PMID 31184789.
- ↑ Enzyme 3.1.4.2 at KEGG Pathway Database.