Glycerophosphocholine cholinephosphodiesterase
| glycerophosphocholine cholinephosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.38 | ||||||||
| CAS no. | 60063-78-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme glycerophosphocholine cholinephosphodiesterase (EC 3.1.4.38) is an enzyme that catalyzes the reaction
The enzyme characterised from rat brain hydrolyses glycerophosphorylcholine to its components glycerol and choline phosphate.[1][2][3]
This enzyme is a hydrolase, specifically one acting on phosphoric diester bonds. The systematic name is sn-glycero-3-phosphocholine cholinephosphohydrolase. This enzyme is also called L-3-glycerylphosphinicocholine cholinephosphohydrolase.[4]
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1WRA.
See also
- Glycerophosphocholine phosphodiesterase which hydrolyses glycerophosphorylcholine to (R)-glyceryl 1-phosphate and choline
References
- ↑ Abra RM, Quinn PJ (1975). "A novel pathway for phosphatidylcholine catabolism in rat brain homogenates". Biochim. Biophys. Acta. 380 (3): 436–41. doi:10.1016/0005-2760(75)90111-3. PMID 166661.
- ↑ Abra, R.M.; Quinn, P.J. (1976). "Some characteristics of sn-glycero-3-phosphocholine diesterases from rat brain". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 431 (3): 631–639. doi:10.1016/0005-2760(76)90227-7. PMID 181064.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "Glycerophosphocholine cholinephosphodiesterase". Enzyme Handbook 3. pp. 615–617. doi:10.1007/978-3-642-76463-9_128. ISBN 978-3-642-48962-4.
- ↑ Enzyme 3.1.4.38 at KEGG Pathway Database.
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