Gluconokinase
| Gluconokinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Gluconokinase homodimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.1.12 | ||||||||
| CAS no. | 9030-55-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Gluconokinase (EC 2.7.1.12) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from yeast and Escherichia coli converts the hexose sugar, D-gluconic acid, to 6-phospho-D-gluconic acid by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2] The enzyme is also found in mammalian kidney[3] and Pseudomonas fluorescens.[4]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-gluconate 6-phosphotransferase. Other names in common use include gluconokinase (phosphorylating), and gluconate kinase.[5]
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1KNQ, PDB: 1KO1, PDB: 1KO4, PDB: 1KO5, PDB: 1KO8, and PDB: 1KOF.
References
- ↑ Cohen, Seymour S. (1951). "Gluconokinase and the Oxidative Path of Glucose-6-Phosphate Utilization". Journal of Biological Chemistry. 189 (2): 617–628. doi:10.1016/S0021-9258(18)44878-8. PMID 14832279.
- ↑ Sable, Henry Z.; Guarino, Armand J. (1952). "Phosphorylation of Gluconate in Yeast Extracts". Journal of Biological Chemistry. 196: 395–402. doi:10.1016/S0021-9258(18)55743-4. PMID 12980980.
- ↑ Leder, I.G. (1957). "Hog Kidney Gluconokinase". Journal of Biological Chemistry. 225: 125–136. doi:10.1016/S0021-9258(18)64915-4. PMID 13416223.
- ↑ Narrod, S.A.; Wood, W.A. (1956). "Carbohydrate Oxidation by Pseudomonas fluorescens". Journal of Biological Chemistry. 220: 45–55. doi:10.1016/S0021-9258(18)65331-1.
- ↑ Enzyme 2.7.1.12 at KEGG Pathway Database.
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