Geranylgeraniol 18-hydroxylase

Geranylgeraniol 18-hydroxylase
Identifiers
EC no.1.14.14.146
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Geranylgeraniol 18-hydroxylase (EC 1.14.14.146, GGOH-18-hydroxylase) is an enzyme with systematic name geranylgeraniol,NADPH:oxygen oxidoreductase (18-hydroxylating).[1] It catalyses the following chemical reaction

2D representation of the chemical structure of geranylgeraniol .
geranylgeraniol
 
O2
2 H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of plaunotol .
plaunotol

Geranylgeraniol 18-hydroxylase is a cytochrome P450 protein containing heme, isolated from Croton sublyratus. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate.[2]

References

  1. ↑ Tansakul P, De-Eknamkul W (1998). "Geranylgeraniol-18-hydroxylase: the last enzyme in the plaunotol biosynthetic pathway in Croton sublyratus". Phytochemistry. 47 (7): 1241–1246. Bibcode:1998PChem..47.1241T. doi:10.1016/s0031-9422(97)00743-7.
  2. ↑ Enzyme 1.14.14.146 at KEGG Pathway Database.
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