GDP-D-glucose phosphorylase
| GDP-D-glucose phosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.7.78 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
GDP-D-glucose phosphorylase (EC 2.7.7.78) is an enzyme with systematic name GDP:alpha-D-glucose 1-phosphate guanylyltransferase.[1] It catalyses the following chemical reaction:
The enzyme characterised from Caenorhabditis elegans helps prevent the misincorporation of glucose in place of mannose residues into glycoconjugates by removing any GDP-glucose present.[2] This compound may arise because the biosynthesis of ascorbic acid requires the enzyme GDP-L-galactose phosphorylase but this can give the unwanted GDP-glucose as well as its main product, GDP-β-L-galactose.[3]
References
- ↑ Enzyme 2.7.7.78 at KEGG Pathway Database.
- ↑ Adler LN, Gomez TA, Clarke SG, Linster CL (June 2011). "A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals". The Journal of Biological Chemistry. 286 (24): 21511–23. doi:10.1074/jbc.m111.238774. PMC 3122210. PMID 21507950.
- ↑ Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG (June 2007). "Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants". The Journal of Biological Chemistry. 282 (26): 18879–85. doi:10.1074/jbc.m702094200. PMC 2556065. PMID 17462988.
External links
- GDP-D-glucose+phosphorylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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