Fucose-1-phosphate guanylyltransferase
| Fucose-1-phosphate guanylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.7.30 | ||||||||
| CAS no. | 9033-14-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from pig liver combines guanosine triphosphate and β-L-fucose 1-phosphate to give GDP-L-fucose, with pyrophosphate (PPi) as a byproduct.[1] The sugar starting material is biosynthesised by fucokinase and the product is used by all fucosyltransferases.[2] This is a salvage pathway for L-fucose.[3][4]
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:beta-L-fucose-1-phosphate guanylyltransferase. Other names in common use include GDP fucose pyrophosphorylase, guanosine diphosphate L-fucose pyrophosphorylase, GDP-L-fucose pyrophosphorylase, GDP-fucose pyrophosphorylase, and GTP:L-fucose-1-phosphate guanylyltransferase.[5]
References
- ↑ Ishihara H, Heath EC (1968). "The metabolism of L-fucose. IV. The biosynthesis of guanosine diphosphate L-fucose in porcine liver". J. Biol. Chem. 243 (6): 1110–5. doi:10.1016/S0021-9258(19)56959-9. PMID 5646162.
- ↑ Ng, Bobby G.; Rosenfeld, Jill A.; Emrick, Lisa; et al. (2018). "Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation". The American Journal of Human Genetics. 103 (6): 1030–1037. doi:10.1016/j.ajhg.2018.10.021. PMC 6288200. PMID 30503518.
- ↑ Norton, Pamela A.; Mehta, Anand S. (2019). "Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review". World Journal of Gastroenterology. 25 (23): 2947–2960. doi:10.3748/wjg.v25.i23.2947. PMC 6589740. PMID 31249452.
- ↑ Cao, Chenqi; Bai, Yi; Zhang, Mengxin; Khan, Shahin Shah; Ji, Yu; Liu, Luo (2025). "Synthesis of 2′-fucosyllactose using multi-enzyme cascade with cofactor regeneration". Scientific Reports. 16 (1) 2457. doi:10.1038/s41598-025-32265-7. PMC 12820362. PMID 41390687.
- ↑ Enzyme 2.7.7.30 at KEGG Pathway Database.