FADS1

FADS1
Identifiers
Aliases	FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12, fatty acid desaturase 1
External IDs	OMIM: 606148; MGI: 1923517; GeneCards: FADS1
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 1.14.19.44 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.2 Start 61,799,627 bp End 61,829,318 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 10,160,252 bp End 10,174,241 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh ventral tegmental area superior vestibular nucleus ventricular zone spinal ganglia internal globus pallidus ganglionic eminence trigeminal ganglion inferior ganglion of vagus nerve subthalamic nucleus Top expressed in adrenal gland tail of embryo genital tubercle choroid plexus of fourth ventricle Epithelium of choroid plexus left lobe of liver sciatic nerve superior frontal gyrus dentate gyrus of hippocampal formation granule cell vestibular membrane of cochlear duct More reference expression data BioGPS n/a
Gene ontology Molecular function C-5 sterol desaturase activity oxidoreductase activity omega-6 fatty acid desaturase activity acyl-CoA delta5-desaturase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle mitochondrion endoplasmic reticulum Biological process linoleic acid metabolic process regulation of transcription, DNA-templated lipid metabolism cellular response to starvation cell-cell signaling alpha-linolenic acid metabolic process fatty acid metabolic process icosanoid biosynthetic process fatty acid biosynthetic process phospholipid biosynthetic process unsaturated fatty acid biosynthetic process regulation of cell differentiation regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 3992 76267 Ensembl ENSG00000149485 ENSMUSG00000010663 UniProt O60427 Q920L1 RefSeq (mRNA) NM_013402 NM_146094 RefSeq (protein) NP_037534 NP_666206 Location (UCSC) Chr 11: 61.8 – 61.83 Mb Chr 19: 10.16 – 10.17 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Fatty acid desaturase 1 (FADS1) is an enzyme that in humans is encoded by the FADS1 gene.

Function

The protein encoded by the FADS1 gene is a member of the fatty acid desaturase (FADS) gene family and desaturates omega-3 and omega-6 polyunsaturated fatty acids at the delta-5 position, catalyzing the final step in the formation of eicosapentaenoic acid (EPA) and arachidonic acid. Desaturase enzymes (such as those encoded by FADS1) regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

Clinical significance

Single nucleotide polymorphisms (SNPs) of FADS1 and FADS2 may affect long-chain polyunsaturated fatty acids (LC-PUFA) metabolism and have a potential role in the development of atopic diseases.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Stöhr H, Marquardt A, Rivera A, Cooper PR, Nowak NJ, Shows TB, et al. (January 1998). "A gene map of the Best's vitelliform macular dystrophy region in chromosome 11q12-q13.1". Genome Research. 8 (1): 48–56. doi:10.1101/gr.8.1.48. PMC 310689. PMID 9445487.
• Cho HP, Nakamura M, Clarke SD (2000). "Cloning, expression, and fatty acid regulation of the human delta-5 desaturase". The Journal of Biological Chemistry. 274 (52): 37335–37339. doi:10.1074/jbc.274.52.37335. PMID 10601301.
• Leonard AE, Kelder B, Bobik EG, Chuang LT, Parker-Barnes JM, Thurmond JM, et al. (May 2000). "cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid". The Biochemical Journal. 347 Pt 3 (Pt 3): 719–724. doi:10.1042/0264-6021:3470719. PMC 1221008. PMID 10769175.
• Marquardt A, Stöhr H, White K, Weber BH (2000). "cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family". Genomics. 66 (2): 175–183. doi:10.1006/geno.2000.6196. PMID 10860662.
• Brizio C, Galluccio M, Wait R, Torchetti EM, Bafunno V, Accardi R, et al. (June 2006). "Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase". Biochemical and Biophysical Research Communications. 344 (3): 1008–1016. Bibcode:2006BBRC..344.1008B. doi:10.1016/j.bbrc.2006.04.003. PMID 16643857.
• Schaeffer L, Gohlke H, Müller M, Heid IM, Palmer LJ, Kompauer I, et al. (June 2006). "Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids". Human Molecular Genetics. 15 (11): 1745–1756. doi:10.1093/hmg/ddl117. PMID 16670158.
• Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (March 2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
• Dreesen TD, Adamson AW, Tekle M, Tang C, Cho HP, Clarke SD, et al. (August 2006). "A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 75 (2): 97–106. doi:10.1016/j.plefa.2006.05.001. PMID 16846730.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Risé P, Ghezzi S, Carissimi R, Mastromauro F, Petroni A, Galli C (October 2007). "Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells". European Journal of Pharmacology. 571 (2–3): 97–105. doi:10.1016/j.ejphar.2007.06.021. PMID 17655842.