Erythritol kinase
| Erythritol kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.27 | ||||||||
| CAS no. | 9030-64-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Erythritol kinase (EC 2.7.1.27) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Propionibacterium pentosaceum converts the sugar alcohol, erythritol, to D-erythritol 4-phosphate, by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:erythritol 4-phosphotransferase. This enzyme is also called erythritol kinase (phosphorylating).[3]
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1V5S.
References
- ↑ Shetter, Janette K. (1956). "Formation of D-Erythritol 4-Phosphate by Propionibacterium pentosaceum". Journal of the American Chemical Society. 78 (15): 3722–3723. doi:10.1021/ja01596a047.
- ↑ Holten, Darold; Fromm, Herbert J. (1961). "Purification and Properties of Erythritol Kinase from Propionibacterium pentosaceum". Journal of Biological Chemistry. 236 (10): 2581–2584. doi:10.1016/S0021-9258(19)61702-3.
- ↑ Enzyme 2.7.1.27 at KEGG Pathway Database.
Categories: