Diphosphate-purine nucleoside kinase
| diphosphate-purine nucleoside kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.143 | ||||||||
| CAS no. | 70356-41-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Diphosphate-purine nucleoside kinase (EC 2.7.1.143) is an enzyme that catalyzes the general chemical reaction
- diphosphate + a purine nucleoside phosphate + a purine mononucleotide
For example, it can convert guanosine to guanosine monophosphate:
The enzyme was characterised from the Acholeplasma class of Mollicutes.[1][2]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is diphosphate:purine nucleoside phosphotransferase. This enzyme is also called pyrophosphate-purine nucleoside kinase.[3]
References
- ↑ Tryon VV, Pollack D (1984). "Purine metabolism in Acholeplasma laidlawii B: novel PPi-dependent nucleoside kinase activity". J. Bacteriol. 159 (1): 265–70. doi:10.1128/jb.159.1.265-270.1984. PMC 215623. PMID 6330034.
- ↑ Tryon VV, Pollack JD (1985). "Distinctions in Mollicutes purine metabolism: pyrophosphate-dependent nucleoside kinase and dependence on guanylate salvage". Int. J. Syst. Bacteriol. 35 (4): 497–501. doi:10.1099/00207713-35-4-497.
- ↑ Enzyme 2.7.1.143 at KEGG Pathway Database.
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