Dephospho-CoA kinase
| Dephospho-CoA kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.24 | ||||||||
| CAS no. | 9026-83-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Dephospho-CoA kinase (EC 2.7.1.24) is an enzyme that catalyzes the final chemical reaction in the biosynthesis of coenzyme A:[1]
The reaction transfers a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[2][3][4]
This enzyme is a transferases, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:dephospho-CoA 3'-phosphotransferase. Other names in common use include dephosphocoenzyme A kinase (phosphorylating), 3'-dephospho-CoA kinase, and dephosphocoenzyme A kinase.[5]
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1JJV, PDB: 1N3B, PDB: 1T3H, PDB: 1VHL, PDB: 1VHT, PDB: 1VIY, PDB: 2GRJ, and PDB: 2IF2.
References
- ↑ Leonardi R, Jackowski S (April 2007). "Biosynthesis of Pantothenic Acid and Coenzyme A". EcoSal Plus. 2 (2) 10.1128/ecosalplus.3.6.3.4. doi:10.1128/ecosalplus.3.6.3.4. PMC 4950986. PMID 26443589.
- ↑ Abiko Y (1970). "Pantothenic acid and coenzyme A: Dephospho-CoA pyrophosphorylase and dephospho-CoA kinase as a possible bifunctional enzyme complex (ATP: Pantetheine-4′-phosphate adenyltransferase, EC 2.7.7.3 and ATP: Dephospho-CoA 3′-phosphotransferase, EC 2.7.1.24)". Vitamins and Coenzymes. Methods Enzymol. Vol. 18A. pp. 358–364. doi:10.1016/0076-6879(71)18327-9. ISBN 978-0-12-181879-1.
- ↑ Hoagland MB, Novelli GD (1954). "Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate". J. Biol. Chem. 207 (2): 767–73. doi:10.1016/S0021-9258(18)65696-0. PMID 13163064.
- ↑ Wang TP, Kaplan NO (1954). "Kinases for the synthesis of coenzyme A and triphosphopyridine nucleotide". J. Biol. Chem. 206 (1): 311–325. doi:10.1016/S0021-9258(18)71320-3. PMID 13130551.
- ↑ Enzyme 2.7.1.24 at KEGG Pathway Database.