Deoxysarpagine hydroxylase
| Deoxysarpagine hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.136 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Deoxysarpagine hydroxylase (EC 1.14.14.136) is an enzyme that catalyzes the chemical reaction
10-deoxysarpagine
O2
H2O
sarpagine
The enzyme is a cytochrome P450 protein containing heme, isolated from Rauvolfia species. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate. The systematic name of this enzyme class is 10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating). It is also called DOSH. The compounds are indole alkaloids.[1][2]
References
- ↑ Yu B, Ruppert M, Stockigt J (2002). "Deoxysarpagine hydroxylase--a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia". Bioorg. Med. Chem. 10 (8): 2479–2483. doi:10.1016/S0968-0896(02)00126-8. PMID 12057637.
- ↑ Enzyme 1.14.14.136 at KEGG Pathway Database.