STYXL2

STYXL2
Identifiers
Aliases	STYXL2, dual specificity phosphatase 27 (putative), dual specificity phosphatase 27, atypical, serine/threonine/tyrosine interacting like 2, DUSP27
External IDs	MGI: 2685055; GeneCards: STYXL2
Gene location (Human) Chr. Chromosome 1 (human) Band 1q24.1 Start 167,094,075 bp End 167,129,165 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H2.3 Start 165,925,717 bp End 165,955,491 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle cardiac muscle tissue of right atrium tibialis anterior muscle Skeletal muscle tissue of rectus abdominis deltoid muscle apex of heart right ventricle quadriceps femoris muscle vastus lateralis muscle biceps brachii Top expressed in interventricular septum knee joint medial head of gastrocnemius muscle soleus muscle muscle of thigh quadriceps femoris muscle skeletal muscle tissue tibialis anterior muscle temporal muscle triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine/serine/threonine phosphatase activity phosphatase activity Cellular component cytoplasm sarcomere Biological process protein dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 92235 240892 Ensembl ENSG00000198842 ENSMUSG00000026564 UniProt Q5VZP5 Q148W8 RefSeq (mRNA) NM_001080426 NM_001033344 NM_001160049 RefSeq (protein) NP_001073895 NP_001028516 NP_001153521 Location (UCSC) Chr 1: 167.09 – 167.13 Mb Chr 1: 165.93 – 165.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine/tyrosine-interacting-like 2 is a protein that in humans is encoded by the STYXL2 gene (previously DUSP27). Though it is homologous to certain dual-specificity phosphatases, a conserved cysteine in the putative active site has been replaced by a serine, suggesting that it may no longer function as a phosphatase.

Further reading

• Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A (December 2009). "Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study". Eur. J. Hum. Genet. 17 (12): 1650–7. doi:10.1038/ejhg.2009.94. PMC 2783544. PMID 19536175.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.