Cefdaloxime

Cefdaloxime
Clinical data
ATC code	None;
Identifiers
CAS Number	80195-36-4;
PubChem CID	9571072;
ChemSpider	7845538;
UNII	6856HDT30F;
ChEMBL	ChEMBL2104469;
CompTox Dashboard (EPA)	DTXSID801001097 ;
Chemical and physical data
Formula	C14H15N5O6S2
Molar mass	413.42 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\O)/c3nc(sc3)N)COC)C(=O)O;
	InChI InChI=1S/C14H15N5O6S2/c1-25-2-5-3-26-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-27-14(15)16-6/h4,8,12,24H,2-3H2,1H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1; Key:HOGISBSFFHDTRM-GHXIOONMSA-N;
	(verify)

Cefdaloxime (INN) is a third-generation cephalosporin antibiotic.^[1] Developed in the late 1980's by Hoechst-Roussel Pharmaceuticals Inc.,^[2] it was never brought to market.^[3]

References

↑ Sader HS, Runyon BA, Erwin ME, Jones RN (February 1995). "Antimicrobial activity of 11 newer and investigational drugs tested against aerobic isolates from spontaneous bacterial peritonitis". Diagnostic Microbiology and Infectious Disease. 21 (2): 105–110. doi:10.1016/0732-8893(94)00148-p. PMID 7628189.
↑ Jones RN, Erwin ME (May 1992). "Preliminary disk diffusion susceptibility testing criteria for cefdaloxime (RU29246, HR-916 metabolite), a new orally administered cephalosporin". Journal of Clinical Microbiology. 30 (5): 1297–1300. doi:10.1128/jcm.30.5.1297-1300.1992. PMC 265269. PMID 1583135.
↑ Zagursky RJ, Pichichero ME (2018). "Cross-reactivity in β-Lactam Allergy". The Journal of Allergy and Clinical Immunology. In Practice. 6 (1): 72–81.e1. doi:10.1016/j.jaip.2017.08.027. PMID 29017833.

[Sader_1995-1] Sader HS, Runyon BA, Erwin ME, Jones RN (February 1995). "Antimicrobial activity of 11 newer and investigational drugs tested against aerobic isolates from spontaneous bacterial peritonitis". Diagnostic Microbiology and Infectious Disease. 21 (2): 105–110. doi:10.1016/0732-8893(94)00148-p. PMID 7628189.

[2] Jones RN, Erwin ME (May 1992). "Preliminary disk diffusion susceptibility testing criteria for cefdaloxime (RU29246, HR-916 metabolite), a new orally administered cephalosporin". Journal of Clinical Microbiology. 30 (5): 1297–1300. doi:10.1128/jcm.30.5.1297-1300.1992. PMC 265269. PMID 1583135.

[3] Zagursky RJ, Pichichero ME (2018). "Cross-reactivity in β-Lactam Allergy". The Journal of Allergy and Clinical Immunology. In Practice. 6 (1): 72–81.e1. doi:10.1016/j.jaip.2017.08.027. PMID 29017833.

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