Carbazole 1,9a-dioxygenase
| Carbazole 1,9a-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.22 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Carbazole 1,9a-dioxygenase (EC 1.14.12.22, CARDO) is an enzyme with systematic name 9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction
The four substrates of the enzyme are carbazole, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are 2'-aminobiphenyl-2,3-diol and oxidised NAD+. It is an oxidoreductase that uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. It catalyses the first reaction in the pathway of carbazole degradation.[3]
References
- ↑ Nam JW, Nojiri H, Noguchi H, Uchimura H, Yoshida T, Habe H, Yamane H, Omori T (December 2002). "Purification and characterization of carbazole 1,9a-dioxygenase, a three-component dioxygenase system of Pseudomonas resinovorans strain CA10". Applied and Environmental Microbiology. 68 (12): 5882–90. Bibcode:2002ApEnM..68.5882N. doi:10.1128/aem.68.12.5882-5890.2002. PMC 134387. PMID 12450807.
- ↑ Gai Z, Wang X, Liu X, Tai C, Tang H, He X, Wu G, Deng Z, Xu P (April 2010). "The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5". PLOS ONE. 5 (4) e10018. Bibcode:2010PLoSO...510018G. doi:10.1371/journal.pone.0010018. PMC 2848856. PMID 20368802.
- ↑ Enzyme 1.14.12.22 at KEGG Pathway Database.
External links
- Carbazole+1,9a-dioxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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