Carbachol/brimonidine

Carbachol/brimonidine
Combination of
CarbacholCholinergic agonist
BrimonidineAlpha-adrenergic receptor agonist
Clinical data
Trade namesYuvezzi
Other namesBrimochol PF
AHFS/Drugs.comMonograph
MedlinePlusa626030
License data
Routes of
administration		Ophthalmic
ATC code
  • None
Legal status
Legal status

Carbachol/brimonidine, sold under the brand name Yuvezzi, is a fixed-dose combination medication used for the treatment of presbyopia.[1] It contains carbachol, a cholinergic agonist; and brimonidine, as the salt brimonidine tartrate, an alpha-adrenergic receptor agonist.[1] It is given via an eye drop.[1]

Medical uses

The combination is indicated for the treatment of presbyopia in adults.[1]

Mechanism of action

The combination works by combining carbachol and brimonidine tartrate, the tartrate salt form of brimonidine to work together to constrict the pupil, called miosis.[2][3]

Carbachol

Carbachol constricts the pupil, creating a pinhole effect which lets only the most direct and focused light into the eye. This results in closer objects appearing clearer.[2]

Brimonidine

Brimonidine keeps the pupil from widening again by relaxing opposing muscles in the iris and reducing unnecessary muscle activity. This results in the pupil-constricting effect carbachol does to last longer and remain more controlled. This maintains pupil size that supports clear near vision throughout the day.[2]

Society and culture

Brimonidine/carbachol was approved for medical use in the United States in January 2026.[2]

Brand names

Brimonidine/carbachol is sold under the brand name Yuvezzi.[1]

References

  1. 1 2 3 4 5 6 "Yuvezzi- carbachol and brimonidine tartrate solution/ drops". DailyMed. 27 May 2026. Retrieved 26 July 2026.
  2. 1 2 3 4 "Yuvezzi: Uses, Dosage, Side Effects, Warnings Drugs.com". Drugs.com. Retrieved 9 July 2026.
  3. ↑ "Yuvezzi (Carbachol/Brimonidine): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". www.webmd.com. Retrieved 9 July 2026.
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