Calcineurin-like phosphoesterase

Available protein structures:
PDB	IPR004843 PF00149 (ECOD; PDBsum)
AlphaFold	IPR004843; PF00149;

Metallophos
Metallophos
	5'-nucleotidase (open form) complex with atp
Identifiers
Symbol	Metallophos
Pfam	PF00149
Pfam clan	CL0163
InterPro	IPR004843
SCOP2	1fjm / SCOPe / SUPFAM
OPM superfamily	389
OPM protein	3tgh
CDD	cd00838
Membranome	585
PDB
Available protein structures:
PDB	IPR004843 PF00149 (ECOD; PDBsum)
AlphaFold	IPR004843; PF00149;

The calcineurin-like phosphoesterases are a family of enzymes related to calcineurin. It includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as some bacterial nucleases. The most conserved region is a centre on the metal chelating residues.^[1]

References

↑ Aravind L, Koonin EV (August 1998). "Phosphoesterase domains associated with DNA polymerases of diverse origins". Nucleic Acids Research. 26 (16): 3746–52. doi:10.1093/nar/26.16.3746. PMC 147763. PMID 9685491.

This article incorporates text from the public domain Pfam and InterPro: IPR004843

[pmid9685491-1] Aravind L, Koonin EV (August 1998). "Phosphoesterase domains associated with DNA polymerases of diverse origins". Nucleic Acids Research. 26 (16): 3746–52. doi:10.1093/nar/26.16.3746. PMC 147763. PMID 9685491.

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