CTP-dependent riboflavin kinase
| CTP-dependent riboflavin kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.161 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
CTP-dependent riboflavin kinase (EC 2.7.1.161, Methanocaldococcus jannaschii Mj0056, Mj0056) is an enzyme with systematic name CTP:riboflavin 5′-phosphotransferase. This enzyme catalyses the following chemical reaction
The enzyme characterised from Methanocaldococcus jannaschii converts riboflavin to flavin mononucleotide by transferring a phosphate group from the cofactor, cytidine triphosphate (CTP), which is converted to cytidine diphosphate (CDP).[1]
This archaeal enzyme uses CTP as the donor nucleotide, rather than adenosine triphosphate as used in many species that contain the enzyme riboflavin kinase.[1][2]
References
- 1 2 Ammelburg M, Hartmann MD, Djuranovic S, Alva V, Koretke KK, Martin J, Sauer G, Truffault V, Zeth K, Lupas AN, Coles M (December 2007). "A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels". Structure. 15 (12): 1577–90. doi:10.1016/j.str.2007.09.027. PMID 18073108.
- ↑ Enzyme 2.7.1.161 at KEGG Pathway Database.
External links
- CTP-dependent+riboflavin+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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