Aromatic-hydroxylamine O-acetyltransferase
| Aromatic-hydroxylamine O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.56 | ||||||||
| CAS no. | 52660-15-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Aromatic-hydroxylamine O-acetyltransferase (EC 2.3.1.56) is an enzyme that catalyzes the rearrangement of an acetyl group from a nitrogen atom in a hydroxylamine derivative (an acetohydroxamic acid) to the oxygen atom of the parent hydroxylamine. The enzyme was characterised from rat liver.[1]
The two substrates of this enzyme are N-hydroxy-4-acetylaminobiphenyl and N-hydroxy-4-aminobiphenyl. The former molecule is converted to the N-hydroxy-4-aminobiphenyl while the latter becomes N-acetoxy-1,1'-biphenyl-4-amine after receiving the transferred acetyl group.[1]
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase. Other names in common use include aromatic hydroxylamine acetyltransferase, arylhydroxamate acyltransferase, arylhydroxamate N,O-acetyltransferase, arylhydroxamic acid N,O-acetyltransferase, arylhydroxamic acyltransferase, N,O-acetyltransferase, and N-hydroxy-2-acetylaminofluorene N-O acyltransferase.[2]
References
- 1 2 Bartsch H, Dworkin C, Miller EC, Miller JA (1973). "Formation of electrophilic N-acetoxyarylamines in cytosoles from rat mammary gland and other tissues by transacetylation from the carcinogen N-hydroxy-4-acetylaminobiphenyl". Biochim. Biophys. Acta. 304 (1): 42–55. doi:10.1016/0304-4165(73)90113-x. PMID 4699998.
- ↑ Enzyme 2.3.1.56 at KEGG Pathway Database.