Anhydro-N-acetylmuramic acid kinase
| Anhydro-N-acetylmuramic acid kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.170 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Anhydro-N-acetylmuramic acid kinase (EC 2.7.1.170, anhMurNAc kinase, AnmK) is an enzyme with systematic name ATP:1,6-anhydro-N-acetyl-beta-muramate 6-phosphotransferase.[1] It catalyses the following chemical reaction
The enzyme characterised from Escherichia coli and Pseudomonas aeruginosa converts 1,6-anhydro-N-acetyl-β-muramic acid to N-acetylmuramic acid 6-phosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[2][3][4]
The product is then converted to N-acetyl-D-glucosamine 6-phosphate by N-acetylmuramic acid 6-phosphate etherase. This sequence allows these organisms to recycle their cell wall.[2][5]
References
- ↑ Enzyme 2.7.1.170 at KEGG Pathway Database.
- 1 2 Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT (June 2005). "Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate". Journal of Bacteriology. 187 (11): 3643–9. doi:10.1128/jb.187.11.3643-3649.2005. PMC 1112033. PMID 15901686.
- ↑ Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT (February 2006). "MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall". Journal of Bacteriology. 188 (4): 1660–2. doi:10.1128/jb.188.4.1660-1662.2006. PMC 1367226. PMID 16452451.
- ↑ Bacik JP, Whitworth GE, Stubbs KA, Yadav AK, Martin DR, Bailey-Elkin BA, Vocadlo DJ, Mark BL (April 2011). "Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase". The Journal of Biological Chemistry. 286 (14): 12283–91. doi:10.1074/jbc.m110.198317. PMC 3069431. PMID 21288904.
- ↑ Jaeger T, Mayer C (March 2008). "N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism". Cellular and Molecular Life Sciences. 65 (6): 928–39. doi:10.1007/s00018-007-7399-x. PMC 11131651. PMID 18049859.
External links
- Anhydro-N-acetylmuramic+acid+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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