Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase
| Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.8.37 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase (EC 2.7.8.37) is an enzyme with systematic name ATP:methylphosphonate 5-triphosphoribosyltransferase.[1] It catalyses the following chemical reaction:
- ATP + methylphosphonate alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine
This enzyme characterised from the bacterium Escherichia coli produces α-D-ribose 1-methylphosphonate 5-triphosphate by reacting methylphosphonic acid with adenosine triphosphate (ATP), which gives adenine as a byproduct.[2] This is part of a pathway that allows microorganisms to metabolise carbon-phosphorus bonds.[3]
References
- ↑ Enzyme 2.7.8.37 at KEGG Pathway Database.
- ↑ Kamat, Siddhesh S.; Williams, Howard J.; Raushel, Frank M. (2011). "Intermediates in the transformation of phosphonates to phosphate by bacteria". Nature. 480 (7378): 570–573. doi:10.1038/nature10622. PMC 3245791. PMID 22089136.
- ↑ McGrath, John W.; Chin, Jason P.; Quinn, John P. (2013). "Organophosphonates revealed: New insights into the microbial metabolism of ancient molecules". Nature Reviews Microbiology. 11 (6): 412–419. doi:10.1038/nrmicro3011. PMID 23624813.
External links
- Alpha-D-ribose+1-methylphosphonate+5-triphosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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