Albendazole monooxygenase
| Albendazole monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.32 | ||||||||
| CAS no. | 101299-59-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Albendazole monooxygenase (EC 1.14.13.32) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are albendazole, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen and a proton. Its products are ricobendazole (albendazole S-oxide), oxidised NADP+, and water.[1][2][3]
This enzyme is coded by the gene for FMO3[1] and is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming). Other names in common use include albendazole oxidase, and albendazole sulfoxidase. It employs one cofactor, flavin adenine dinucleotide.[1]
See also
A similar oxidation is carried out by EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming), which in humans is known to be carried out by CYP3A4 and CYP2J2.[3][4]
References
- 1 2 3 Enzyme 1.14.13.32 at KEGG Pathway Database.
- ↑ Fargetton X, Galtier P, Delatour P (1986). "Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes". Vet. Res. Commun. 10 (4): 317–324. doi:10.1007/BF02213995. PMID 3739217.
- 1 2 Rawden, Helen C.; Kokwaro, Gilbert O.; Ward, Stephen A.; Edwards, Geoffrey (2000). "Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes". British Journal of Clinical Pharmacology. 49 (4): 313–322. doi:10.1046/j.1365-2125.2000.00170.x. PMC 2014938. PMID 10759686.
- ↑ EC 1.14.14.73