Acetyl-CoA C-acetyltransferase
| Acetyl-CoA C-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystallographic structure of the tetrameric acetoacetyl-CoA thiolase (EC:2.3.1.9) from the Gram-negative bacterium Z. ramigera.[1] | |||||||||
| Identifiers | |||||||||
| EC no. | 2.3.1.9 | ||||||||
| CAS no. | 9027-46-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Acetyl-CoA C-acetyltransferase (EC 2.3.1.9) is an enzyme that catalyzes the chemical reaction
The enzyme has one substrate, acetyl-CoA, and converts two molecules of this into acetoacetyl-CoA and coenzyme A.[2][3]
Acetyl-CoA C-acetyltransferase has a cysteine at its active site, and is a transferase in the group of acyltransferases which transfer groups other than aminoacyl groups. Its systematic name is acetyl-CoA:acetyl-CoA C-acetyltransferase. Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in many metabolic pathways including fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, propanoate metabolism, and butanoate metabolism.[4]
Isozymes
Human genes encoding acetyl-CoA C-acetyltransferases include:
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References
- ↑ PDB: 2WKT; Meriläinen G, Poikela V, Kursula P, Wierenga RK (November 2009). "The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate of the Claisen condensation". Biochemistry. 48 (46): 11011–25. doi:10.1021/bi901069h. PMID 19842716.
- ↑ Lynen F, Ochoa S (1953). "Enzymes of fatty acid metabolism". Biochim. Biophys. Acta. 12 (1–2): 299–314. doi:10.1016/0006-3002(53)90149-8. PMID 13115439. S2CID 1546557.
- ↑ Stern JR, Drummond GI, Coon MJ, del Campillo A (1960). "Enzymes of ketone body metabolism. I. Purification of an acetoacetate-synthesizing enzyme from ox liver". J. Biol. Chem. 235 (2): 313–317. doi:10.1016/S0021-9258(18)69521-3. PMID 13834445.
- ↑ Enzyme 2.3.1.9 at KEGG Pathway Database.