ATP adenylyltransferase
ATP adenylyltransferase (EC 2.7.7.53) is an enzyme that catalyzes the chemical reaction:
| ATP adenylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.7.53 | ||||||||
| CAS no. | 96697-71-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme characterised from Saccharomyces cerevisiae and Myxococcus xanthus combines adenosine triphosphate and adenosine triphosphate to give Ap4A, with orthophosphate (Pi) as a byproduct.[1][2] Ap4A has been suggested to be an alarmone, a compound produced when an organism is damaged or exposed to heat stress.[3]
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ADP:ATP adenylyltransferase. Other names in common use include bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming), diadenosinetetraphosphate alphabeta-phosphorylase, adenine triphosphate adenylyltransferase, diadenosine 5',5'"-P1,P4-tetraphosphate alphabeta-phosphorylase, (ADP-forming), and dinucleoside oligophosphate alphabeta-phosphorylase.[4]
References
- ↑ Guranowski A, Blanquet S (1985). "Phosphorolytic cleavage of diadenosine 5',5-P1,P4-tetraphosphate Properties of homogeneous diadenosine 5',5-P1,P4-tetraphosphate alpha, beta-phosphorylase from Saccharomyces cerevisiae". J. Biol. Chem. 260 (6): 3542–7. doi:10.1016/S0021-9258(19)83656-6. PMID 2982863.
- ↑ Kimura, Yoshio; Tanaka, Chihiro; Oka, Manami (July 2018). "Identification of Major Enzymes Involved in the Synthesis of Diadenosine Tetraphosphate and/or Adenosine Tetraphosphate in Myxococcus xanthus". Current Microbiology. 75 (7): 811–817. doi:10.1007/s00284-018-1452-x. ISSN 1432-0991. PMID 29468302. S2CID 3402370.
- ↑ Despotović, Dragana; Brandis, Alexander; Savidor, Alon; Levin, Yishai; Fumagalli, Laura; Tawfik, Dan S. (2017). "Diadenosine tetraphosphate (Ap4A) – an E. coli alarmone or a damage metabolite?". The FEBS Journal. 284 (14): 2194–2215. doi:10.1111/febs.14113. hdl:2434/503672. ISSN 1742-4658. PMID 28516732.
- ↑ Enzyme 2.7.7.53 at KEGG Pathway Database.