7-Dimethylallyltryptophan synthase
| 7-dimethylallyltryptophan synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.80 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
7-dimethylallyltryptophan synthase (EC 2.5.1.80, 7-DMATS) is an enzyme with systematic name dimethylallyl-diphosphate:L-tryptophan 7-dimethylallyltransferase.[1] It catalyses the following chemical reaction which adds a prenyl group from dimethylallyl pyrophosphate to L-tryptophan, specifically in its 7-position, giving 7-(3-methylbut-2-enyl)-L-tryptophan, with pyrophosphate (PPi) as byproduct:[2]
-L-tryptophan.svg.png)
This enzyme characterised from Aspergillus fumigatus is more flexible towards the aromatic substrate than tryptophan dimethylallyltransferase.[3]
References
- ↑ Enzyme 2.5.1.80 at KEGG Pathway Database.
- ↑ Kremer A, Westrich L, Li SM (October 2007). "A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus: overproduction, purification and biochemical characterization". Microbiology. 153 (Pt 10): 3409–16. doi:10.1099/mic.0.2007/009019-0. PMID 17906140.
- ↑ Kremer A, Li SM (July 2008). "Potential of a 7-dimethylallyltryptophan synthase as a tool for production of prenylated indole derivatives". Applied Microbiology and Biotechnology. 79 (6): 951–61. doi:10.1007/s00253-008-1505-3. PMID 18481055.
External links
- 7-dimethylallyltryptophan+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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