Tryptophan dimethylallyltransferase
| Tryptophan dimethylallyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.34 | ||||||||
| CAS no. | 55127-01-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Tryptophan dimethylallyltransferase (EC 2.5.1.34) is an enzyme that catalyzes the chemical reaction
-L-tryptophan.svg.png)
The two substrates of this enzyme characterised from ergot fungi are tryptophan and dimethylallyl pyrophosphate. Its products are 4-(3-methylbut-2-enyl)-L-tryptophan and pyrophosphate (PPi). This is a step in the biosynthesis of ergot alkaloids.[1]
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase. Other names in common use include dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase, dimethylallyltryptophan synthetase, dimethylallylpyrophosphate:tryptophan dimethylallyl transferase, DMAT synthetase, and 4-(gamma,gamma-dimethylallyl)tryptophan synthase.[2]
References
- ↑ Lee SL, Floss HG, Heinstein P (1976). "Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58". Arch. Biochem. Biophys. 177 (1): 84–94. doi:10.1016/0003-9861(76)90418-5. PMID 999297.
- ↑ Enzyme 2.5.1.34 at KEGG Pathway Database.