5-dehydro-2-deoxygluconokinase
| 5-dehydro-2-deoxygluconokinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.92 | ||||||||
| CAS no. | 62213-35-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
5-dehydro-2-deoxygluconokinase (EC 2.7.1.92) is an enzyme that catalyzes the following chemical reaction:
The enzyme characterised from Aerobacter aerogenes converts 2-deoxy-D-gluc-5-ulosonic acid to its monophosphate, 6-phospho-5-dehydro-2-deoxy-D-gluconic acid by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP). This is part of the breakdown of myo-inositol in this organism.[1]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 5-keto-2-deoxygluconokinase, 5-keto-2-deoxyglucono kinase (phosphorylating), and DKH kinase.[2]
References
- ↑ Anderson WA, Magasanik B (1971). "The pathway of myo-inositol degradation in Aerobacter aerogenes: Conversion of 2-deoxy-5-keto-D-gluconic acid to glycolytic intermediates". J. Biol. Chem. 246 (18): 5662–75. doi:10.1016/S0021-9258(18)61857-5. PMID 4328832.
- ↑ Enzyme 2.7.1.92 at KEGG Pathway Database.
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