4-nitrophenol 2-monooxygenase

4-nitrophenol 2-monooxygenase
Identifiers
EC no.1.14.13.29
CAS no.91116-87-9
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

4-nitrophenol 2-monooxygenase (EC 1.14.13.29) is an enzyme that catalyzes the chemical reaction

+ NADH + H+
 
 
O2
H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q230010.
4-Nitrocatechol
+ NAD+
 

The four substrates of this enzyme are 4-nitrophenol, reduced nicotinamide adenine dinucleotide (NADH), oxygen. and a proton. Its products are 4-nitrocatechol, oxidised NAD+, and water.[1][2]

The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is 4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating). Other names in common use include 4-nitrophenol hydroxylase, and 4-nitrophenol-2-hydroxylase.[1]

References

  1. 1 2 Enzyme 1.14.13.29 at KEGG Pathway Database.
  2. ↑ Mitra D, Vaidyanathan CS (1984). "A new 4-nitrophenol 2-hydroxylase from a Nocardia sp". Biochem. Int. 8 (5): 609–15. PMID 6477623.