4-chlorophenylacetate 3,4-dioxygenase
| 4-chlorophenylacetate 3,4-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.9 | ||||||||
| CAS no. | 105006-00-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
4-chlorophenylacetate 3,4-dioxygenase (EC 1.14.12.9) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are 4-chlorophenylacetic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are 3,4-dihydroxyphenylacetic acid, oxidised NAD+, and hydrochloric acid.[1][2]
This enzyme is an oxidoreductase, which uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. The systematic name of the enzyme class is 4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating). It is an iron–sulfur protein that is part of tyrosine metabolism.[1]
References
- 1 2 Enzyme 1.14.12.9 at KEGG Pathway Database.
- ↑ Markus A, Krekel D, Lingens F (1986). "Purification and some properties of component A of the 4-chlorophenylacetate 3,4-dioxygenase from Pseudomonas species strain CBS". J. Biol. Chem. 261 (27): 12883–8. doi:10.1016/S0021-9258(18)67175-3. PMID 3745216.