3',5'-cyclic-GMP phosphodiesterase
| 3′,5′-cyclic-GMP phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.35 | ||||||||
| CAS no. | 9068-52-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme 3′,5′-cyclic-GMP phosphodiesterase (EC 3.1.4.35) catalyzes the reaction
The enzyme characterised from mice hydrolyses cyclic guanosine monophosphate (3',5'-cyclic GMP) to guanosine monophosphate. Unlike the enzyme cyclic nucleotide phosphodiesterase (EC 3.1.4.17) this reaction is specific to 3',5'-cyclic GMP.[1][2][3]
This enzyme is a hydrolase, specifically one acting on phosphoric diester bonds. The systematic name is 3′,5′-cyclic-GMP 5'-nucleotidohydrolase. Other names in use include guanosine cyclic 3',5'-phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3′,5′-GMP phosphodiesterase, cyclic guanosine 3′,5′-monophosphate phosphodiesterase, cyclic guanosine 3′,5′-phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3′,5′-phosphate phosphodiesterase.[4]
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1MC0, PDB: 2CHM, PDB: 2H40, PDB: 2H42, and PDB: 2H44.
References
- ↑ Marks F, Raab I (1974). "The second messenger system of mouse epidermis. IV. Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368–377. doi:10.1016/0005-2744(74)90180-6.
- ↑ Francis, Sharron H.; Corbin, Jackie D. (1988). "Purification of CGMP-binding protein phosphodiesterase from rat lung". Initiation and Termination of Cyclic Nucleotide Action. Methods in Enzymology. Vol. 159. pp. 722–729. doi:10.1016/0076-6879(88)59067-5. ISBN 978-0-12-182060-2. PMID 2842633.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "3′, 5′-Cyclic-GMP phosphodiesterase". Enzyme Handbook 3. pp. 599–603. doi:10.1007/978-3-642-76463-9_125. ISBN 978-3-642-48962-4.
- ↑ Enzyme 3.1.4.35 at KEGG Pathway Database.