| 2010 Game Log (65–97) |
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record |
| 1 | April 5 | San Diego | 6–3 | Haren (1–0) | Garland (0–1) | None | 49,192 | 1–0 |
| 2 | April 6 | San Diego | 3–6 | Young (1–0) | Jackson (0–1) | Bell (1) | 19,177 | 1–1 |
| 3 | April 7 | San Diego | 5–3 | Boyer (1–0) | Correia (0–1) | Qualls (1) | 17,673 | 2–1 |
| 4 | April 9 | Pittsburgh | 9–1 | López (1–0) | Morton (0–1) | None | 21,316 | 3–1 |
| 5 | April 10 | Pittsburgh | 3–6 | Duke (2–0) | Haren (1–1) | Dotel (1) | 22,400 | 3–2 |
| 6 | April 11 | Pittsburgh | 15–6 | Jackson (1–1) | McCutchen (0–1) | None | 21,093 | 4–2 |
| 7 | April 13 | @ Los Angeles | 9–5 | Kershaw (1–0) | Kennedy (0–1) | None | 56,000 | 4–3 |
| 8 | April 14 | @ Los Angeles | 7–9 | Rosales (1–0) | Ortiz (0–1) | None | 44,621 | 5–3 |
| 9 | April 15 | @ Los Angeles | 6–5 | Broxton (1–0) | Boyer (1–1) | None | 39,697 | 5–4 |
| 10 | April 16 | @ San Diego | 6–3 | Bell (1–0) | Gutiérrez (0–1) | None | 26,632 | 5–5 |
| 11 | April 17 | @ San Diego | 5–0 | Correia (2–1) | Benson (0–1) | None | 31,324 | 5–6 |
| 12 | April 18 | @ San Diego | 5–3 | Mujica (1–0) | Heilman (0–1) | Bell (3) | 20,634 | 5–7 |
| 13 | April 19 | St. Louis | 2–4 | Penny (2–0) | Boyer (1–2) | Franklin (5) | 24,167 | 5–8 |
| 14 | April 20 | St. Louis | 9–7 | Haren (2–1) | Boggs (0–1) | Qualls (2) | 19,855 | 6–8 |
| 15 | April 21 | St. Louis | 4–9 | Motte (1–1) | Qualls (0–1) | None | 19,165 | 6–9 |
| 16 | April 23 | Philadelphia | 7–4 | Benson (1–1) | Hamels (2–2) | Qualls (3) | 25,980 | 7–9 |
| 17 | April 24 | Philadelphia | 2–3 | Contreras (1–1) | Gutiérrez (0–2) | Madson (4) | 33,323 | 7–10 |
| 18 | April 25 | Philadelphia | 8–6 | Rosales (2–0) | Herndon (0–1) | Qualls (4) | 29,296 | 8–10 |
| 19 | April 26 | @ Colorado | 3–5 | Haren (3–1) | Hammel (0–2) | Qualls (5) | 20,308 | 9–10 |
| 20 | April 27 | @ Colorado | 12–1 | Jiménez (5–0) | Jackson (1–2) | None | 24,112 | 9–11 |
| 21 | April 28 | @ Colorado | 11–12 | Howry (1–0) | Morales (0–2) | Gutiérrez (1) | 23,773 | 10–11 |
| 22 | April 29 | @ Chicago | 5–13 | Kennedy (1–1) | Lilly (1–1) | None | 36,850 | 11–11 |
| 23 | April 30 | @ Chicago | 11–5 | Wells (3–0) | López (1–1) | None | 37,800 | 11–12 |
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| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record |
| 24 | May 1 | @ Chicago | 7–5 | Marshall (1–1) | Gutiérrez (0–3) | Mármol (4) | 40,368 | 11–13 |
| 25 | May 2 | @ Chicago | 10–5 | Gorzelanny (1–3) | Jackson (1–3) | None | 38,144 | 11–14 |
| 26 | May 3 | @ Houston | 1–9 | Valdez (1–0) | Paulino (0–4) | None | 20,370 | 12–14 |
| 27 | May 4 | @ Houston | 0–1 | Kennedy (2–1) | Oswalt (2–4) | Qualls (5) | 22,661 | 13–14 |
| 28 | May 5 | @ Houston | 4–2 | Lindstrom (1–0) | Gutiérrez (0–4) | None | 21,030 | 13–15 |
| 29 | May 6 | @ Houston | 3–6 | Haren (4–1) | Rodríguez (1–4) | None | 21,019 | 14–15 |
| 30 | May 7 | Milwaukee | 2–3 | Gallardo (4–2) | Jackson (1–4) | Hoffman (5) | 27,067 | 14–16 |
| 31 | May 8 | Milwaukee | 3–17 | Wolf (3–2) | Valdez (1–1) | None | 26,877 | 14–17 |
| 32 | May 9 | Milwaukee | 1–6 | Narveson (3–0) | Kennedy (2–2) | None | 25,358 | 14–18 |
| 33 | May 10 | Los Angeles | 3–7 | Billingsley (3–2) | López (1–2) | None | 19,863 | 14–19 |
| 34 | May 11 | Los Angeles | 3–13 | Ely (1–1) | Haren (4–2) | None | 21,030 | 14–20 |
| 35 | May 12 | Los Angeles | 3–6 | Kuroda (4–1) | Jackson (1–5) | Broxton (4) | 22,714 | 14–21 |
| 36 | May 14 | @ Atlanta | 6–5 | Wagner (2–0) | Qualls (0–2) | None | 30,657 | 14–22 |
| 37 | May 15 | @ Atlanta | 1–11 | López (2–2) | Hanson (3–3) | None | 32,718 | 15–22 |
| 38 | May 16 | @ Atlanta | 13–1 | Hudson (4–1) | Haren (4–3) | None | 31,758 | 15–23 |
| 39 | May 17 | @ Florida | 1–5 | Jackson (2–5) | Volstad (3–4) | None | 10,870 | 16–23 |
| 40 | May 18 | @ Florida | 8–0 | Johnson (4–1) | Buckner (0–1) | None | 13,289 | 16–24 |
| 41 | May 19 | San Francisco | 13–1 | Kennedy (3–2) | Wellemeyer (3–3) | None | 17,073 | 17–24 |
| 42 | May 20 | San Francisco | 8–7 | Heilman (1–1) | Affeldt (2–3) | Qualls (7) | 18,607 | 18–24 |
| 43 | May 21 | Toronto | 8–6 | Haren (5–3) | Morrow (3–4) | Qualls (8) | 19,531 | 19–24 |
| 44 | May 22 | Toronto | 8–5 | Jackson (3–5) | Eveland (3–4) | Qualls (9) | 32,746 | 20–24 |
| 45 | May 23 | Toronto | 4–12 | Marcum (4–1) | Buckner (0–2) | None | 23,148 | 20–25 |
| 46 | May 25 | @ Colorado | 3–2 | Chacín (3–2) | Kennedy (3–3) | Corpas (4) | 28,370 | 20–26 |
| 47 | May 26 | @ Colorado | 7–3 | Jiménez (9–1) | López (2–3) | None | 26,320 | 20–27 |
| 48 | May 27 | @ Colorado | 8–2 | Hammel (2–3) | Haren (5–4) | None | 28,353 | 20–28 |
| 49 | May 28 | @ San Francisco | 5–0 | Cain (3–4) | Jackson (3–6) | None | 31,495 | 20–29 |
| 50 | May 29 | @ San Francisco | 12–1 | Sánchez (3–4) | Buckner (0–3) | None | 37,400 | 20–30 |
| 51 | May 30 | @ San Francisco | 6–5 | Wilson (1–0) | Rosa (0–1) | None | 41,394 | 20–31 |
| 52 | May 31 | @ Los Angeles | 5–4 | Broxton (3–0) | Vásquez (0–1) | None | 45,325 | 20–32 |
|
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record |
| 53 | June 1 | @ Los Angeles | 1–0 | Weaver (3–1) | Gutiérrez (0–5) | None | 36,533 | 20–33 |
| 54 | June 2 | @ Los Angeles | 1–0 | Schlichting (1–0) | Valdez (1–2) | None | 35,355 | 20–34 |
| 55 | June 4 | Colorado | 7–6 | Qualls (1–2) | Corpas (1–3) | None | 25,290 | 21–34 |
| 56 | June 5 | Colorado | 4–3 | Willis (2–2) | Chacín (3–4) | Qualls (10) | 28,138 | 22–34 |
| 57 | June 6 | Colorado | 3–2 | Jiménez (11–1) | López (2–4) | Corpas (6) | 20,793 | 22–35 |
| 58 | June 7 | Atlanta | 7–4 | Haren (6–4) | Lowe (8–5) | Qualls (11) | 17,731 | 23–35 |
| 59 | June 8 | Atlanta | 5–7 | Venters (1–0) | Vásquez (0–2) | Wagner (10) | 17,052 | 23–36 |
| 60 | June 9 | Atlanta | 2–1 | Heilman (2–1) | Moylan (2–1) | Qualls (12) | 19,138 | 24–36 |
| 61 | June 10 | Atlanta | 7–11 | Moylan (2–2) | Qualls (1–3) | Wagner (11) | 26,969 | 24–37 |
| 62 | June 11 | St. Louis | 2–5 | García (6–2) | López (2–5) | Franklin (11) | 20,629 | 24–38 |
| 63 | June 12 | St. Louis | 7–2 | Haren (7–4) | Ottavino (0–2) | None | 30,017 | 25–38 |
| 64 | June 13 | St. Louis | 7–5 | Vásquez (1–2) | McClellan (0–2) | None | 23,922 | 26–38 |
| 65 | June 15 | @ Boston | 6–3 | Buchholz (9–4) | Kennedy (3–4) | Papelbon (14) | 37,459 | 26–39 |
| 66 | June 16 | @ Boston | 6–2 | Lester (8–2) | López (2–6) | Papelbon (15) | 37,452 | 26–40 |
| 67 | June 17 | @ Boston | 8–5 | Lackey (8–3) | Haren (7–5) | None | 37,544 | 26–41 |
| 68 | June 18 | @ Detroit | 7–5 | Coke (5–0) | Qualls (1–5) | Valverde (15) | 37,438 | 26–42 |
| 69 | June 19 | @ Detroit | 5–6 | Jackson (4–6) | Porcello (4–7) | Heilman (1) | 40,681 | 27–42 |
| 70 | June 20 | @ Detroit | 3–1 | Scherzer (4–6) | Kennedy (3–5) | Valverde (16) | 41,417 | 27–43 |
| 71 | June 21 | Yankees | 10–4 | López (3–6) | Burnett (6–6) | None | 47,229 | 28–43 |
| 72 | June 22 | Yankees | 3–9 | Pettitte (9–2) | Haren (7–6) | None | 45,776 | 28–44 |
| 73 | June 23 | Yankees | 5–6 | Rivera (1–1) | Rosa (0–2) | None | 46,325 | 28–45 |
| 74 | June 25 | @ Tampa Bay | 0–1 | Jackson (5–6) No-Hitter | Niemann (6–2) | None | 18,918 | 29–45 |
| 75 | June 26 | @ Tampa Bay | 5–3 | Price (11–3) | Kennedy (3–6) | Soriano (18) | 23,945 | 29–46 |
| 76 | June 27 | @ Tampa Bay | 1–2 | López (4–6) | Davis (5–9) | Heilman (2) | 25,442 | 30–46 |
| 77 | June 28 | @ St. Louis | 6–5 | Motte (3–2) | Heilman (2–2) | None | 41,578 | 30–47 |
| 78 | June 29 | @ St. Louis | 8–0 | Wainwright (11–5) | Willis (2–3) | None | 38,736 | 30–48 |
| 79 | June 30 | @ St. Louis | 2–4 | Enright (1–0) | Suppan (0–4) | Heilman (3) | 36,962 | 31–48 |
|
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record |
| 80 | July 2 | Los Angeles | 12–5 | Jackson (6–6) | Kuroda (7–6) | None | 23,115 | 32–48 |
| 81 | July 3 | Los Angeles | 1–14 | Kershaw (8–4) | López (4–7) | None | 44,169 | 32–49 |
| 82 | July 4 | Los Angeles | 1–3 | Kuo (3–1) | Heilman (2–3) | Broxton (17) | 26,517 | 32–50 |
| 83 | July 5 | Chicago | 4–9 | Gorzelanny (3–5) | Kennedy (3–7) | None | 26,250 | 32–51 |
| 84 | July 6 | Chicago | 4–6 | Silva (9–2) | Enright (1–1) | Mármol (16) | 20,067 | 32–52 |
| 85 | July 7 | Chicago | 3–8 | Dempster (7–7) | Jackson (6–7) | None | 20,914 | 32–53 |
| 86 | July 8 | Florida | 10–4 | López (5–7) | Sánchez (7–6) | None | 16,664 | 33–53 |
| 87 | July 9 | Florida | 2–3 | Nolasco (9–6) | Haren (7–7) | Núñez (19) | 18,117 | 33–54 |
| 88 | July 10 | Florida | 5–4 | Kennedy (4–7) | Robertson (6–7) | Gutiérrez (2) | 21,627 | 34–54 |
| 89 | July 11 | Florida | 0–2 | Badenhop (1–5) | Enright (1–2) | Núñez (20) | 21,037 | 34–55 |
| 90 | July 16 | @ San Diego | 12–1 | Garland (9–6) | Haren (7–8) | None | 33,177 | 34–56 |
| 91 | July 17 | @ San Diego | 8–5 | Richard (7–4) | López (5–8) | Bell (25) | 40,011 | 34–57 |
| 92 | July 18 | @ San Diego | 6–4 | Correia (6–6) | Jackson (6–8) | Bell (26) | 25,363 | 34–58 |
| 93 | July 19 | Mets | 13–2 | Kennedy (5–7) | Pelfrey (10–5) | None | 18,253 | 35–58 |
| 94 | July 20 | Mets | 3–2 | Enright (2–2) | Dickey (6–4) | Gutiérrez (3) | 18,749 | 36–58 |
| 95 | July 21 | Mets | 4–3 | Boyer (2–2) | Nieve (0–0) | None | 18,223 | 37–58 |
| 96 | July 22 | San Francisco | 0–3 | Cain (8–8) | López (5–9) | Wilson (27) | 17,230 | 37–59 |
| 97 | July 23 | San Francisco | 4–7 | Ray (3–0) | Jackson (6–9) | Wilson (28) | 22,512 | 37–60 |
| 98 | July 24 | San Francisco | 4–10 | Bumgarner (4–2) | Kennedy (5–8) | None | 32,774 | 37–61 |
| 99 | July 25 | San Francisco | 2–3 | Romo (3–3) | Vásquez (1–3) | Wilson (29) | 31,278 | 37–62 |
| 100 | July 27 | @ Philadelphia | 9–5 | Herndon (1–2) | Norberto (0–2) | None | 44,379 | 37–63 |
| 101 | July 28 | @ Philadelphia | 7–1 | Halladay (12–8) | Jackson (6–10) | None | 45,048 | 37–64 |
| 102 | July 29 | @ Philadelphia | 3–2 | Contreras (5–3) | Vásquez (1–4) | None | 45,232 | 37–65 |
| 103 | July 30 | @ Mets | 6–9 | Kennedy (6–8) | Valdés (2–3) | Heilman (4) | 34,280 | 38–65 |
| 104 | July 31 | @ Mets | 5–4 | Rodríguez (4–2) | Gutiérrez 0–6 | None | 35,287 | 38–66 |
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| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record |
| 105 | August 1 | @ Mets | 1–14 | Hudson (2–1) | Niese (7–5) | None | 35,014 | 39–66 |
| 106 | August 2 | Washington | 1–3 | Hernández (8–7) | López (5–10) | Burnett (1) | 16,793 | 39–67 |
| 107 | August 3 | Washington | 6–1 | Saunders (7–10) | Olsen (3–3) | None | 17,164 | 40–67 |
| 108 | August 4 | Washington | 2–7 | Stammen (4–4) | Kennedy (6–9) | None | 15,670 | 40–68 |
| 109 | August 5 | Washington | 8–4 | Enright (3–2) | Detwiler (0–2) | None | 16,638 | 41–68 |
| 110 | August 6 | San Diego | 2–1 | Hudson (3–1) | Garland (10–8) | Heilman (5) | 22,168 | 42–68 |
| 111 | August 7 | San Diego | 6–5 | Heilman (3–3) | Gregerson (3–6) | None | 48,946 | 43–68 |
| 112 | August 8 | San Diego | 1–10 | Latos (12–5) | Saunders (7–11) | None | 27,856 | 43–69 |
| 113 | August 9 | @ Milwaukee | 4–7 | Demel (1–0) | Hoffman (2–5) | Heilman (6) | 29,633 | 44–69 |
| 114 | August 10 | @Milwaukee | 1–2 | Boyer (3–2) | Capuano (1–2) | Demel (1) | 35,029 | 45–69 |
| 115 | August 11 | @ Milwaukee | 2–8 | Hudson (4–1) | Bush (5–10) | None | 29,611 | 46–69 |
| 116 | August 12 | @ Milwaukee | 8–4 | Wolf (9–9) | López (5–11) | Axford (17) | 34,808 | 46–70 |
| 117 | August 13 | @ Washington | 4–2 | Lannan (4–5) | Saunders (7–12) | Burnett (2) | 19,549 | 46–71 |
| 118 | August 14 | @ Washington | 2–9 | Kennedy (7–9) | Marquis (0–5) | None | 22,400 | 47–71 |
| 119 | August 15 | @ Washington | 5–3 | Clippard (9–6) | Norberto (0–2) | Storen (2) | 21,695 | 47–72 |
| 120 | August 17 | Cincinnati | 2–6 | Arroyo (13–7) | Hudson (4–2) | None | 21,502 | 47–73 |
| 121 | August 18 | Cincinnati | 7–11 | Rhodes (4–3) | Heilman (3–4) | None | 15,509 | 47–74 |
| 122 | August 19 | Cincinnati | 5–9 | Wood (4–1) | Saunders (7–13) | None | 17,385 | 47–75 |
| 123 | August 20 | Colorado | 4–3 | Heilman (4–4) | Beimel (1–2) | None | 26,294 | 48–75 |
| 124 | August 21 | Colorado | 3–1 | Enright (3–2) | Jiménez (17–4) | Gutiérrez (4) | 37,631 | 49–75 |
| 125 | August 22 | Colorado | 0–1 | Chacín (6–9) | Heilman (4–5) | Street (10) | 30,397 | 49–76 |
| 126 | August 24 | @ San Diego | 5–0 | Richard (12–5) | López (5–12) | None | 20,075 | 49–77 |
| 127 | August 25 | @ San Diego | 9–3 | LeBlanc (8–11) | Saunders (7–14) | None | 21,966 | 49–78 |
| 128 | August 26 | @ San Diego | 5–11 | Kennedy (8–9) | Correia (10–9) | None | 20,983 | 50–78 |
| 129 | August 27 | @ San Francisco | 0–6 | Enright (5–2) | Lincecum (10–9) | None | 38,013 | 51–78 |
| 130 | August 28 | @ San Francisco | 3–11 | Hudson (5–2) | Zito (8–10) | None | 41,250 | 52–78 |
| 131 | August 29 | @ San Francisco | 9–7 | Affeldt (3–3) | Vásquez (1–5) | Wilson (36) | 38,735 | 52–79 |
| 132 | August 30 | San Diego | 7–2 | Saunders (8–14) | LeBlanc (8–12) | None | 17,829 | 53–79 |
| 133 | August 31 | San Diego | 7–4 | Kennedy (9–9) | Correia (10–10) | Gutiérrez (5) | 16,250 | 54–79 |
|
| # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record |
| 134 | September 1 | San Diego | 5–2 | Enright (6–2) | Gregerson (3–7) | Gutiérrez (6) | 17,606 | 55–79 |
| 135 | September 3 | Houston | 4–3 | Heilman (5–5) | López (5–1) | Gutiérrez (7) | 24,764 | 56–79 |
| 136 | September 4 | Houston | 5–6 | Melancon (2–0) | Heilman (5–6) | Lyon (12) | 31,621 | 56–80 |
| 137 | September 5 | Houston | 2–3 | Happ (6–2) | López (5–13) | Lyon (13) | 25,449 | 56–81 |
| 138 | September 6 | San Francisco | 0–2 | Casilla (6–2) | Heilman (5–7) | Wilson (41) | 31,904 | 56–82 |
| 139 | September 7 | San Francisco | 3–6 | Lincecum (13–9) | Enright (6–3) | Affeldt (4) | 19,423 | 56–83 |
| 140 | September 8 | San Francisco | 3–1 | Hudson (5–1) | Zito (8–12) | Gutiérrez (8) | 19,971 | 57–83 |
| 141 | September 10 | @ Colorado | 13–4 | de la Rosa (7–4) | Saunders (2–5) | None | 37,265 | 57–84 |
| 142 | September 11 | @ Colorado | 2–1 | Reynolds (1–0) | López (5–14) | Street (18) | 48,023 | 57–85 |
| 143 | September 12 | @ Colorado | 4–2 | Street (3–4) | Demel (1–1) | None | 41,504 | 57–86 |
| 144 | September 13 | @ Cincinnati | 7–2 | Arroyo (15–10) | Enright (6–4) | None | 12,060 | 57–87 |
| 145 | September 14 | @ Cincinnati | 1–3 | Hudson (6–1) | Wood (5–3) | Gutiérrez (9) | 16,973 | 58–87 |
| 146 | September 15 | @ Cincinnati | 7–5 | Maloney (1–2) | Saunders (2–6) | Cordero (36) | 19,923 | 58–88 |
| 147 | September 16 | @ Cincinnati | 1–3 | López (6–14) | Vólquez (3–3) | Gutiérrez (10) | 22,090 | 59–88 |
| 148 | September 17 | @ Pittsburgh | 4–3 | Meek (5–4) | Vásquez (1–6) | None | 22,939 | 59–89 |
| 149 | September 18 | @ Pittsburgh | 9–6 | McDonald (4–5) | Enright (6–5) | None | 25,981 | 59–90 |
| 150 | September 19 | @ Pittsburgh | 4–3 | Hanrahan (4–1) | Heilman (5–8) | Meek (3) | 18,331 | 59–91 |
| 151 | September 21 | Colorado | 3–1 | Saunders (3–6) | de la Rosa (8–5) | Gutiérrez (11) | 37,461 | 60–91 |
| 152 | September 22 | Colorado | 8–4 | López (7–14) | Jiménez (19–7) | Demel (2) | 29,916 | 61–91 |
| 153 | September 23 | Colorado | 10–9 | Carrasco (3–2) | Francis (4–6) | Gutiérrez (12) | 30,090 | 62–91 |
| 154 | September 24 | Los Angeles | 1–3 | Kershaw (13–10) | Enright (6–6) | Jansen (2) | 38,567 | 62–92 |
| 155 | September 25 | Los Angeles | 5–2 | Hudson (7–1) | Ely (4–9) | Gutiérrez (13) | 41,403 | 63–92 |
| 156 | September 26 | Los Angeles | 5–4 | Demel (2–1) | Broxton (5–6) | Gutiérrez (14) | 38,178 | 64–92 |
| 157 | September 28 | @ San Francisco | 4–2 | Sánchez (12–9) | López (7–15) | Wilson (46) | 37,449 | 64–93 |
| 158 | September 29 | @ San Francisco | 3–1 | Lincecum (16–10) | Kennedy (9–10) | Wilson (47) | 38,228 | 64–94 |
| 159 | September 30 | @ San Francisco | 4–1 | Bumgarner (7–6) | Enright (6–7) | Ramírez (1) | 37,261 | 64–95 |
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