2-phospho-L-lactate transferase
| 2-phospho-L-lactate transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.8.28 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-phospho-L-lactate transferase (EC 2.7.8.28, LPPG:Fo 2-phospho-L-lactate transferase, LPPG:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase, MJ1256, lactyl-2-diphospho-(5')guanosine:Fo 2-phospho-L-lactate transferase, CofD) is an enzyme with systematic name (2S)-lactyl-2-diphospho-5'-guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase.[1] It catalyses the following chemical reaction
The enzyme characterised from Methanococcus jannaschii uses (2S)-lactyl-2-diphospho-5'-guanosine to link the terminal hydroxy group of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (1) through a phosphate ester to a lactic acid. Guanosine monophosphate (GMP) is a byproduct. This reaction is part of the biosynthesis of coenzyme F420.[2][3] The enzyme is also present in Paraburkholderia rhizoxinica and many other bacteria and archaea.[4][5]
References
- ↑ Enzyme 2.7.8.28 at KEGG Pathway Database.
- ↑ Graupner M, Xu H, White RH (March 2002). "Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F(420) biosynthesis in Methanococcus jannaschii". Biochemistry. 41 (11): 3754–61. doi:10.1021/bi011937v. PMID 11888293.
- ↑ Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton TB, Montelione GT, Galinier A, White RH, Tong L (April 2008). "Molecular insights into the biosynthesis of the F420 coenzyme". The Journal of Biological Chemistry. 283 (17): 11832–40. doi:10.1074/jbc.m710352200. PMC 2431047. PMID 18252724.
- ↑ Braga, Daniel; Last, Daniel; Hasan, Mahmudul; et al. (2019). "Metabolic Pathway Rerouting in Paraburkholderia rhizoxinica Evolved Long-Overlooked Derivatives of Coenzyme F 420". ACS Chemical Biology. 14 (9): 2088–2094. doi:10.1021/acschembio.9b00605. PMID 31469543.
- ↑ Grinter, Rhys; Greening, Chris (8 September 2021). "Cofactor F420: an expanded view of its distribution, biosynthesis and roles in bacteria and archaea". FEMS Microbiology Reviews. 45 (5) fuab021. doi:10.1093/femsre/fuab021. PMC 8498797. PMID 33851978.
External links
- 2-phospho-L-lactate+transferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)