2-Phospho-L-lactate guanylyltransferase
| 2-Phospho-L-lactate guanylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.7.68 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-Phospho-L-lactate guanylyltransferase (EC 2.7.7.68, CofC, MJ0887) is an enzyme with systematic name GTP:2-phospho-L-lactate guanylyltransferase.[1] This enzyme catalyses the following chemical reaction
The enzyme characterised from methanogenic archaea and Paraburkholderia rhizoxinica combines 2-phospho-L-lactic acid and guanosine triphosphate to give L-lactyl-2-diphospho-5'-guanosine, with pyrophosphate (PPi) as a byproduct. The reaction is part of the biosynthesis of coenzyme F420.[2][3][4][5]
References
- ↑ Enzyme 2.7.7.68 at KEGG Pathway Database.
- ↑ Grochowski, Laura L.; Xu, Huimin; White, Robert H. (2008). "Identification and Characterization of the 2-Phospho-l-lactate Guanylyltransferase Involved in Coenzyme F420 Biosynthesis". Biochemistry. 47 (9): 3033–3037. doi:10.1021/bi702475t. PMID 18260642.
- ↑ Braga, Daniel; Last, Daniel; Hasan, Mahmudul; et al. (2019). "Metabolic Pathway Rerouting in Paraburkholderia rhizoxinica Evolved Long-Overlooked Derivatives of Coenzyme F 420". ACS Chemical Biology. 14 (9): 2088–2094. doi:10.1021/acschembio.9b00605. PMID 31469543.
- ↑ Bashiri, Ghader; Antoney, James; Jirgis, Ehab N. M.; et al. (2019). "A revised biosynthetic pathway for the cofactor F420 in prokaryotes". Nature Communications. 10 (1) 1558. doi:10.1038/s41467-019-09534-x. PMC 6450877. PMID 30952857.
- ↑ Hasan, Mahmudul; Schulze, Sabrina; Berndt, Leona; et al. (2022). "Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F 420 and Its Derivative 3PG-F 420". mBio. 13 (1) e03501-21. doi:10.1128/mbio.03501-21. PMC 8764529. PMID 35038903.
External links
- 2-phospho-L-lactate+guanylyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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