2-Deoxystreptamine glucosyltransferase

2-deoxystreptamine glucosyltransferase
Identifiers
EC no.2.4.1.284
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

2-deoxystreptamine glucosyltransferase (EC 2.4.1.284, kanF (gene)) is an enzyme with systematic name UDP-alpha-D-glucose:2-deoxystreptamine 6-alpha-D-glucosyltransferase.[1] It catalyses the following chemical reaction

2D representation of the chemical structure of Q27103617.
2-deoxystreptamine
+ UDP-glucose
 
 
 
Rightward reaction arrow with minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q27133629.
2'-deamino-2'-hydroxyparomamine
Kanamycin B

This is an early step in the biosynthesis of the aminoglycoside antibiotics, kanamycin B and kanamycin C in Streptomyces kanamyceticus.[2]

References

  1. ↑ Enzyme 2.4.1.284 at KEGG Pathway Database.
  2. ↑ Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ (October 2011). "Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation". Nature Chemical Biology. 7 (11): 843–52. doi:10.1038/nchembio.671. PMID 21983602.
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