2-dehydro-3-deoxygluconokinase
| 2-dehydro-3-deoxygluconokinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 2-Keto-3-deoxygluconate kinase homohexamer, Thermus thermophilus | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.1.45 | ||||||||
| CAS no. | 9026-54-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Escherichia coli converts 2-dehydro-3-deoxy-D-gluconic acid to 2-dehydro-3-deoxy-6-phospho-D-gluconic acid by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 2-keto-3-deoxygluconokinase, 2-keto-3-deoxy-D-gluconic acid kinase, 2-keto-3-deoxygluconokinase (phosphorylating), 2-keto-3-deoxygluconate kinase, and ketodeoxygluconokinase. It participates in the pentose phosphate pathway.[2]
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1WYE.[3]
References
- ↑ Cynkin MA, Ashwell G (June 1960). "Uronic acid metabolism in bacteria. IV. Purification and properties of 2-keto-3-deoxy-D-gluconokinase in Escherichia coli". The Journal of Biological Chemistry. 235 (6): 1576–9. doi:10.1016/S0021-9258(19)76843-4. PMID 13813474.
- ↑ Enzyme 2.7.1.45 at KEGG Pathway Database.
- ↑ Toyoda, T.; Suzuki, K.; Hossain, M.T.; Koike, I.; Sekiguchi, T.; Takenaka, A. (2006). "Crystal structure of 2-keto-3-deoxygluconate kinase (Form 1) from Sulfolobus Tokodaii". doi:10.2210/pdb1WYE/pdb.
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